Ubenimex

Name: Ubenimex
SKU: U0618
Availability: InStock

Product ID U0618

Cas No. 58970-76-6

Purity ≥98%

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Description

Ubenimex, also known as bestatin, is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelotic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.	58970-76-6
Purity	≥98%
Formula	C₁₆H₂₄N₂O₄
Formula Wt.	308.37
Chemical Name	N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4phenylbutyl]-L-leucine
IUPAC Name	(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
Synonym	Bestatin
Melting Point	233-236°C
Solubility	Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	U0618 MSDS PDF
Info Sheet	U0618 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

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Ubenimex

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