LKT Labs

Biochemicals for Life Science Research

Ubenimex

Product ID U0618
Cas No. 58970-76-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $51.60 In stock
50 mg $226.60 In stock
100 mg $452.10 In stock
Bulk Quote

Quicklinks

Description

Ubenimex, also known as bestatin, is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelotic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.

58970-76-6
Purity

≥98%
Formula

C16H24N2O4
Formula Wt.

308.37
Chemical Name

N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4phenylbutyl]-L-leucine
IUPAC Name

(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
Synonym

Bestatin
Melting Point

233-236°C
Solubility

Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

U0618 MSDS PDF
Info Sheet

U0618 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B1977

    Betulin

    Pentacyclic triterpene found in various plant s...

    ≥98%
  • A6982

    Artesunate

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • H9615

    17α-Hydroxyprogesterone Caproate

    Synthetic steroid hormone; ER antagonist.

    ≥98%
  • I0502

    Ibandronate Sodium Monohydrate

    Bisphosphonate.

    ≥98%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • T2834

    Thiolutin

    Dithiolopyrrolone; RNA polymerase inhibitor.

    ≥98%
  • V0045

    Valacyclovir Hydrochloride

    Neuraminidase inhibitor.

    ≥98%
  • S7601

    Statil

    Aldose reductase inhibitor.

    ≥98%
  • L0251

    Laminin Peptide CDPGYIGSR

    Laminin-derived nonapeptide.

    ≥98%
  • K0038

    Kahweol Oleate

    Diterpene found in coffee beans.

    ≥98%
  • D1869

    Deracoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • A5287

    Angiotensinogen (1-14), human

    Peptide fragment, renin substrate, precursor to...

    ≥95%
  • T0299

    Tazobactam Sodium

    β-lactamase inhibitor.

    ≥98%
  • G8101

    Guaifenesin

    Expectorant.

    ≥98%
  • M3321

    Mifepristone

    Synthetic steroid, contraceptive; PR and glucoc...

    ≥98%
  • C5260

    C-type Natriuretic Peptide (1-22), pig/human/rat

    Endogenous cardiomodulatory peptide; NPR-B agon...

    ≥95%
  • G0180

    Gastrin I, human

    Endogenous peptide hormone involved in feeding ...

    ≥98%
  • P0001

    P1 Peptide

    Octapeptide, prevents EGFR-PLCγ association.

    ≥95%
  • F5773

    Fosinopril Sodium

    ACE inhibitor.

    ≥98%