LKT Labs

Biochemicals for Life Science Research

VE-821

VE-821

Product ID V1600
Cas No. 1232410-49-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $53.00 In stock
5 mg $89.00 In stock
10 mg $142.00 In stock
Bulk Quote

Quicklinks

Description

VE-821 is an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest. VE-821 exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. VE-821 decreases phosphorylation of checkpoint kinase (CHK) 1 and induces G2 phase cell cycle arrest in pancreatic cancer cells and leukemia cells, sensitizing them to the effects of radiation.

Product Info

Cas No.

1232410-49-9
Purity

≥98%
Formula

C18H16N4O3S
Formula Wt.

368.41
IUPAC Name

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Synonym

VE821
Solubility

DMSO 74 mg/mL (200.86 mM) Water Insoluble Ethanol Insoluble
Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

V1600 MSDS PDF
Info Sheet

V1600 Info Sheet PDF

References

Flynn RL, Cox KE, Jeitany M, et al. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16;347(6219):273-7. PMID: 25593184.

Vávrová J, Zárybnická L, Lukášová E, et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys. 2013 Nov;52(4):471-9. PMID: 23934411.

Prevo R, Fokas E, Reaper PM, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. PMID: 22825331.

Reaper PM, Griffiths MR, Long JM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. PMID: 21490603.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4496

    Alyssin

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.

    ≥98%
  • M577521

    Monascorubrin

    Bulgarialactone azaphilone

    ≥98%
  • S1970

    Serum Thymic Factor

    Synthetic peptide hormone.

    ≥95%
  • N0262

    Naphazoline Hydrochloride

    α1-adrenergic agonist.

    ≥97%
  • L5660

    Loperamide Hydrochloride

    FIASMA, μOR agonist, potential HCN channel blo...

    ≥98%
  • S3584

    Sivelestat Sodium Tetrahydrate

    Neutrophil elastase inhibitor.

    ≥99%
  • B8275

    n-Butyric Acid

    Fatty acid found in dairy products; HDAC inhibi...

    ≥98%
  • L337521

    Linagliptin

    Modifies microvascular function

    ≥98%
  • A0910

    N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • R5774

    Roscovitine

    CDK inhibitor, L-type Ca2+ channel blocker.

    ≥98%
  • O9257

    16-Oxokahweol

    Synthetic kahweol derivative.

    ≥95%
  • L582694

    Lorlatinib

    Third generation macrocyclic ALK inhibitor.

    ≥98%
  • C0365

    Carvedilol

    FIASMA; α1- and β1/2-adrenergic antagonist.

    ≥98%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enz...

    ≥96%
  • C4656

    Clopidol

    Coccidiostat.

    ≥98%
  • C0033

    Cafestol Stearate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • C9662

    Cyproterone Acetate

    Steroid; AR antagonist.

    ≥98%
  • S5200

    SNA 1

    Sialic-acid sensing lectin.

    ≥98%
  • B1978

    Betulin-3-Acetate

    Pentacyclic triterpene found in various plant s...

    ≥97%