• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Vindoline

Vindoline

Product ID V3355
Cas No. 2182-14-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 In stock
100 mg $255.30 In stock
500 mg $775.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vindoline is a semi-synthetic vinca alkaloid originally found in Catharanthus that exhibits anti-diabetic and antacid activities; it is an intermediate in the synthesis of vinblastine. Unlike other vinca alkaloids, vindoline is only weakly cytotoxic, binding poorly to tubulin. Vindoline increases glucose-stimulated insulin release and inhibits Kv2.1 K+ channels, decreasing outward K+ current and lowering blood glucose, Hb1Ac, and triglyceride levels in animal models of diabetes. Vindoline also inhibits H+/K+ ATPases, potentially decreasing gastric acid secretion.

Product Info

Cas No.

2182-14-1

Purity

≥98%

Formula

C25H32N2O6

Formula Wt.

456.53

Chemical Name

(2β,3β,4β,5α,12β,19α)-4-(Acetyloxy)-6,7-didehydro- 3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic acid methyl ester

IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2(7),3,5,13-tetraene-10-carboxylate

Synonym

Vindolin, NSC 91994

Melting Point

164-165°C

Solubility

Soluble in chloroform or ethanol.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V3355 MSDS PDF

Info Sheet

V3355 Info Sheet PDF

References

Yao XG, Chen F, Li P, et al. Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models. J Ethnopharmacol. 2013 Oct 28;150(1):285-97. PMID: 24012527.

Freitas CS, Baggio CH, Mayer B, et al. Inhibition of gastric H+, K(+)-ATPase activity by compounds from medicinal plants. Nat Prod Commun. 2011 Sep;6(9):1253-4. PMID: 21941891.

Sertel S, Fu Y, Zu Y, et al. Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol. 2011 Mar 15;81(6):723-35. PMID: 21219884.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5272

    Angiotensin, dog/rat

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • T8269

    (S)-ar-Turmerone

    Sesquiterpene found in Curcuma.

    ≥97%
  • L0528

    LBH-589

    HDAC1/2/3/11 inhibitor.

    ≥98%
  • P8370

    Purmorphamine

    Hedgehog and Smo agonist.

    ≥98%
  • C8112

    CUDC-907

    PI3K and HDAC inhibitor.

    ≥98%
  • S7769

    Streptomycin Sulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • I7447

    1-Isothiocyanato-6-(methylsulfenyl)-hexane

    Synthetic ITC, erucin analog.

    ≥98%
  • O4531

    Oligomycin A

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • T4800

    TM3-0089 Sodium Monohydrate

    CRTH2 inhibitor.

    ≥98%
  • A2050

    Aflatoxin G2

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • E544766

    Enterocin

    A bacteriocin

    ≥95%
  • M177531

    Menaquinone-9

    2-methyl-1,4-naphthoquinone derivative

    ≥99%
  • G0245

    Gallocatechin Gallate

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • R3014

    Recombinant TpN 47 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • A6800

    AR-A014418

    GSK-3β inhibitor.

    ≥98%
  • I7559

    Isoliquiritigenin, natural

    Chalcone; SIRT activator, GABA-A positive modul...

    ≥99%
  • I5212

    Indirubin

    Bisindole isomer of indigo found in Indigo natu...

    ≥98%
  • V1871

    Veratridine

    Binds to neurotoxin receptor site 2 on voltage-gat...
    ≥98%
  • P7218

    Pseudoprotodioscin

    Steroidal saponin found in Tribulus, Trigonella...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only