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YM-201636

YM-201636

Product ID Y4802
Cas No. 371942-69-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $145.80 In stock
5 mg $373.60 In stock
10 mg $598.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

YM-201636 is an inhibitor of PIKfyve, decreasing the synthesis of phosphatidylinositol 3,5-disphosphate. YM-210636 decreases muscular contraction-stimulated glucose uptake in vitro and induces autophagy-dependent neuronal death in other cellular models. Additionally, YM-210636 inhibits endomembrane transport and retroviral budding in vitro.

Product Info

Cas No.

371942-69-7

Purity

≥98%

Formula

C25H21N7O3

Formula Wt.

467.49

IUPAC Name

6-amino-N-[3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenyl]pyridine-3-carboxamide

Synonym

PIKfyve Inhibitor

Solubility

DMSO 35 mg/mL (74.86 mM) Water Insoluble Ethanol Insoluble

Appearance

Beige-Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Y4802 MSDS PDF

Info Sheet

Y4802 Info Sheet PDF

References

Liu Y, Lai YC, Hill EV, et al. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem J. 2013 Oct 15;455(2):195-206. PMID: 23905686.

Martin S, Harper CB, May LM, et al. Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. PLoS One. 2013;8(3):e60152. PMID: 23544129.

Jefferies HB, Cooke FT, Jat P, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep. 2008 Feb;9(2):164-70. PMID: 18188180.

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