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YM-201636 is an inhibitor of PIKfyve, decreasing the synthesis of phosphatidylinositol 3,5-disphosphate. YM-210636 decreases muscular contraction-stimulated glucose uptake in vitro and induces autophagy-dependent neuronal death in other cellular models. Additionally, YM-210636 inhibits endomembrane transport and retroviral budding in vitro.
| Cas No. | 371942-69-7 |
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| Purity | ≥98% |
| Formula | C25H21N7O3 |
| Formula Wt. | 467.49 |
| IUPAC Name | 6-amino-N-[3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenyl]pyridine-3-carboxamide |
| Synonym | PIKfyve Inhibitor |
| Solubility | DMSO 35 mg/mL (74.86 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Beige-Yellow Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Liu Y, Lai YC, Hill EV, et al. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem J. 2013 Oct 15;455(2):195-206. PMID: 23905686.
Martin S, Harper CB, May LM, et al. Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death. PLoS One. 2013;8(3):e60152. PMID: 23544129.
Jefferies HB, Cooke FT, Jat P, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep. 2008 Feb;9(2):164-70. PMID: 18188180.