β-Elemene

Name: β-Elemene
SKU: E4418
Availability: InStock

Product ID E4418

Cas No. 515-13-9

Purity ≥98%

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Description

β-Elemene is a sesquiterpene found in various plant sources. This compound exhibits anti-angiogenic and anticancer chemotherapeutic properties by suppressing Notch-1 and decreasing the expression and phosphorylation of Smad3 and altering TGF-β 1 signaling. β-Elemene also displays anti-inflammatory and immunomodulatory properties, suppressing differentiation of Th17 cells and decreasing levels of IL-17, IL-6, and IL-23 in a mouse model of multiple sclerosis. This compound also induces apoptosis and cell cycle arrest in a wide variety of cancer cell lines.

Product Info

Cas No.	515-13-9
Purity	≥98%
Formula	C₁₅H₂₄
Formula Wt.	204.35
Chemical Name	1S,2S,4R)-1-Methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane
IUPAC Name	1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl)cyclohexane
Appearance	Clear and colorless liquid

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	E4418 MSDS PDF
Info Sheet	E4418 Info Sheet PDF

References

He J, Li M, Bao J, et al. β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction. Front Pharmacol. 2024 Oct 17:15:1469180. PMID: 39484165.

Yan B, Zhou Y, Feng S, et al. β -Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells. Evid Based Complement Alternat Med. 2013;2013:268468. PMID: 23710217.

Zhang X, Li Y, Zhang Y, et al. Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors. PLoS One. 2013;8(3):e58719. PMID: 23516540.

Dai ZJ, Tang W, Lu WF, et al. Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell Int. 2013 Mar 14;13(1):27. PMID: 23496852.

Zhang R, Tian A, Zhang H, et al. Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance. J Mol Neurosci. 2011 May;44(1):31-40. PMID: 21246417.

Li QQ, Wang G, Huang F, et al. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug;62(8):1018-27. PMID: 20663036.

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β-Elemene

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