Description
Vindoline is a semi-synthetic vinca alkaloid originally found in Catharanthus that exhibits anti-diabetic and antacid activities; it is an intermediate in the synthesis of vinblastine. Unlike other vinca alkaloids, vindoline is only weakly cytotoxic, binding poorly to tubulin. Vindoline increases glucose-stimulated insulin release and inhibits Kv2.1 K+ channels, decreasing outward K+ current and lowering blood glucose, Hb1Ac, and triglyceride levels in animal models of diabetes. Vindoline also inhibits H+/K+ ATPases, potentially decreasing gastric acid secretion.