LKT Labs

Biochemicals for Life Science Research

Hexarelin

Hexarelin

Product ID H1893
Cas No. 140703-51-1
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $105.00 In stock
5 mg $210.00 In stock
50 mg $1,838.00 In stock
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Description

Hexarelin is a synthetic analog of ghrelin that binds and activates the ghrelin (GHS) receptor. Hexarelin exhibits cardioprotective, anti-fibrotic, antihypertensive, and anti-fertility activities. In animal models of myocardial infarction, hexarelin protects cardiac function. In spontaneously hypertensive rats, hexarelin prevents deposition of collagen, decreases expression of TIMP-1, collagen I, and collagen III, and increases expression of MMP2 and MMP9, decreasing cardiac fibrosis and blood pressure and attenuating left ventricular hypertrophy. Hexarelin also decreases ovulation and number of offspring produced in vivo.

Product Info

Cas No.

140703-51-1
Purity

≥95%
Formula

C47H58N12O6
Formula Wt.

887.0
Chemical Name

L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L- tryptophyl-D-phenylalanyl-L-Lysinamide

IUPAC Name

(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H- imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl] amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3- phenylpropanoyl]amino]hexanamide InChI: InChI=1S/C47H58N12O6/c1-27-34(33-15-7-9-17-37(33)54-27)23-41(58-44(62)35 (49)22-31-25-51-26-53-31)45(63)55-28(2)43(61)57-40(21-30-24-52-36-16-8- 6-14-32(30)36)47(65)59-39(20-29-12-4-3-5-13-29)46(64)56-38(42(50)60)18- 10-11-19-48/h3-9,12-17,24-26,28,35,38-41,52,54H,10-11,18-23,48-49H2, 1-2H3,(H2,50,60)(H,51,53)(H,55,63)(H,56,64)(H,57,61)(H,58,62)(H,59, 65)/t28-,35-,38-,39?,40-,41+/m0/s1
Synonym

Examorelin
Solubility

Soluble in water. Slightly soluble in DMSO, methanol.
Appearance

White to Off-white Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H1893 MSDS PDF
Info Sheet

H1893 Info Sheet PDF

References

Mao Y, Tokudome T, Kishimoto I, et al. One dose of oral hexarelin protects chronic cardiac function after myocardial infarction. Peptides. 2014 Apr 18;56C:156-162. PMID: 24747279.

Xu X, Ding F, Pang J, et al. Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2012 Sep 15;303(6):H703-11. PMID: 22842067.

Puechagut PB, Martini AC, Stutz G, et al. Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin. Reprod Fertil Dev. 2012;24(3):451-60. PMID: 22401277.

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