Description
BAY-1895344 is an inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.
| Product Unit Size | Cost | Quantity | Stock |
|---|
BAY-1895344 is an inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.
| Cas No. | 1876467-74-1 |
|---|---|
| Purity | ≥99% |
| Formula | C20H21N7O |
| Formula Wt. | 375.44 |
| IUPAC Name | 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine |
| Synonym | BAY 1895344, BAY1895344 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Wengner A., Siemeister G. et al. ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. 77(13 Suppl):Abstract nr 836 (2017).
TRPA1 antagonist
PKA substrate.
Tetracyclic sesterpenoid phytotoxin.
β-lactamase inhibitor.
Selective Cannabinoid receptor 2(CB2) inverse a...
CDK7 inhibitor
Water-soluble parthenolide analog; NF-κB inhib...
Staurosporine analog; PKC inhibitor, TrkA/B ant...
Steroidal alkaloid found in Fritillaria; M2 mAC...
Endogenous APP peptide cleavage product, primar...
JAK2 inhibitor.
NSAID; COX-1/2 inhibitor.
Bactericidal
Protease inhibitor.
Inhibitor of PTEFb/CDK9.
Protonophore; chitinase OvCHT1 inhibitor.
Triterpene glycoside found in Glycyrrhiza; 11β...
Phytoestrogen, isoflavone found in various plan...
p110α PI3K inhibitor.
Purine nucleoside analog; DNA chain terminator....