Description
BAY-1895344 is an inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.
| Product Unit Size | Cost | Quantity | Stock |
|---|
BAY-1895344 is an inhibitor of ataxia telangiectasia and Rad3-related kinase (ATR), a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest.
| Cas No. | 1876467-74-1 |
|---|---|
| Purity | ≥99% |
| Formula | C20H21N7O |
| Formula Wt. | 375.44 |
| IUPAC Name | 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine |
| Synonym | BAY 1895344, BAY1895344 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Wengner A., Siemeister G. et al. ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. 77(13 Suppl):Abstract nr 836 (2017).
GSK-3β inhibitor.
Tetracycline; protein translation inhibitor.
Pim-1 inhibitor.
Isoquinoline alkaloid found in a variety of pla...
Endogenous tripeptide, involved in HPA signalin...
Vitamin E component
Side chain attached to various taxanes.
Anthracycline, DNA intercalator; topoisomerase ...
Mycotoxin contaminant found in cereal grains.
Antioxidant, vitamin E derivative found in vege...
Anthracycline, DNA intercalator; topoisomerase ...
ITC, sulforaphane analog.
Atypical amino acid found in Isaria sinclairi, ...
Pt-based DNA cross-linker.
Nucleoside (thymidine) analog; RT inhibitor.
Staurosporine analog; PKC and PKA inhibitor.
Naturally sourced ITC, sulfonyl analog of sulfo...
CHK1 inhibitor.
ROCK inhibitor.
Tetrapeptide, binds cell surface integrins.