Description
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Cas No. | 1640247-87-5 |
|---|---|
| Purity | ≥99% |
| Formula | C22H17ClFN9O |
| Formula Wt. | 477.89 |
| IUPAC Name | 2,4-Diamino-6-({[5-chloro-8-fluoro-4-oxo-3-(3-pyridinyl)-3,4-dihydro-2-quinazolinyl](cyclopropyl)methyl}amino)-5-pyrimidinecarbonitrile |
| Synonym | GS 9901, GS9901 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel L., Chandrasekhar J., et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 59(19):9928-42 (2016). PMID:27660855.
Flavonoid found in Scutellaria; CDK9 inhibitor....
Melanoma-associated antigen.
Water-soluble parthenolide analog; NF-κB inhib...
Inhibitor of EGFR, HER2, VEGFR2, and FLT3.
S-enantiomer of citalopram; SERT inhibitor.
Ethisterone derivative, synthetic steroid, used...
Phenylpropene derivative found in essential oil...
Polyphenol found in many plants and foods.
BTK inhibitor.
AChE and BChE inhibitor.
Fibrate; PPARα agonist, enoyl-CoA reductase in...
VEGFR2, c-Met, RET inhibitor.
Active form of vitamin D, regulates dietary Ca2...
β1-adrenergic antagonist.
Fluoroquinolone; bacterial DNA gyrase inhibitor...
NLRP3 and caspase-1 inhibitor.
p110α PI3K inhibitor.
Flavonol found in Tagetes.
Phenylamino pyridine; Abl, c-Kit, PDGFR, PP2A i...
Amphibian tachykinin neuropeptide.