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Benzbromarone is a non-competitive inhibitor of xanthine oxidase. It has been evaluated as an effective treatment for gout, thanks to its ability to potently inhibit CYP2C9, reducing urate reabsorption which in turn lowers serum urate levels. It has also shown antioxidant effects in rats with angiotensin-II and salt-induced hypertension, where it reduces the presence of oxidative stress markers.
| Cas No. | 3562-84-3 |
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| Purity | ≥99% |
| Formula | C17H12Br2O3 |
| Formula Wt. | 424.09 |
| Chemical Name | (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone |
| IUPAC Name | (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone |
| Synonym | Desuric, Benzbromaron, Urinorm |
| Solubility | Insoluble in water. Soluble in DMSO - ~40 mg/mL. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Azevedo V., Kos I., et al. Benzbromarone in the treatment of gout. Adv Rheumatol. 59(1):37 (2019). PMID: 31391099.
Muraya N., Kadowaki D., et al. Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. Oxi Med Cell Longev. 2018:7635274 (2018). PMID: 29967665.