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Clemastine is a first generation antihistamine. As a histamine H1 antagonist, it has anticholinergic properties. It has also been investigated for its neuroprotective properties. It enhances myelination in the prefrontal cortex in socially isolated mice, and rescues behavioral changes. It also alleviates stress-related depressive-like behavior in mice, and may reduce neuroinflammation in amyotrophic lateral sclerosis.
| Cas No. | 14976-57-9 |
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| Purity | ≥99% |
| Formula | C21H26ClNO • C4H4O4 |
| Formula Wt. | 459.97 |
| IUPAC Name | (E)-but-2-enedioic acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine |
| Synonym | Meclastine fumarate salt, Mecloprodine, (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, |
| Solubility | Very slightly soluble in water and sparingly soluble in ethanol. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Liu J., Dupree J., et al. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. J Neurosci. 36(3):957-62 (2016). PMID: 26791223.
Su W., Zhang T., et al. Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus. Front Cell Neurosci. 12:412 (2018). PMID: 30483062.
Apolloni S., Fabbrizio P., et al. Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. Mol Neurobiol. 53(1):518-531 (2016). PMID: 25482048.