Description
Shikonin is a natural naphthoquinone compound. It has anti-inflammatory, antibacterial, anti-tumor, and hypoglycemic activities. It has also been shown to induce necroptosis and chromatinolysis in glioma cells.
Product Unit Size | Cost | Quantity | Stock |
---|
Shikonin is a natural naphthoquinone compound. It has anti-inflammatory, antibacterial, anti-tumor, and hypoglycemic activities. It has also been shown to induce necroptosis and chromatinolysis in glioma cells.
Cas No. | 517-89-5 |
---|---|
Purity | ≥98% |
Formula | C16H16O5 |
Formula Wt. | 288.29 |
Chemical Name | R(-)-Shikonin |
IUPAC Name | 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione |
Synonym | Isoarnebin 4, (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione, (-)-Shikonin |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Huang B, Wang Q, Jiang L, et al. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Front Pharmacol. 2022 Aug 17;13:926945. PMID: 36059938.
Maeoka R, Ouji Y, Nakazawa T, et al. Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance. Biomed Pharmacother. 2023 Oct;166:115296. PMID: 37557011.
Wang X, Fan L, Wang X, et al. Cyclophilin A contributes to shikonin-induced glioma cell necroptosis and promotion of chromatinolysis. Sci Rep. 2022 Aug 29;12(1):14675. PMID: 36038617.
Xu Z, Huang L, Zhang T, et al. Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3beta signalling. Oncol Lett. 2022 Jul 8;24(3):304. PMID: 35949620.
Adenosine A2A agonist.
Vitamin D, calcitriol prodrug; VDR agonist.
Inhibitor of FAK and ALK.
MEK1/2 inhibitor.
Azoxanthone derivative; S100A12 and S100A13 inh...
4-Hydroxytamoxifen prodrug; FIASMA, SERM, PKC i...
SERM.
Statin; HMG-CoA reductase inhibitor.
Calcitonin-family peptide, involved in vasodila...
Endogenous vitamin D prodrug.
PP2A activator, Sphk1 and PKC inhibitor.
FLT3, PDGFR inhibitor.
Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...
Alters intracellular glutathione levels.
Macrolide; protein translation inhibitor.
Cephalomannine derivative found in Taxus; poten...
Essential fatty acid found in fish oil, involve...
Prodrug
Laminin-derived nonapeptide.
Coccidiostat; mitochondrial respiration inhibit...