Description
Shikonin is a natural naphthoquinone compound. It has anti-inflammatory, antibacterial, anti-tumor, and hypoglycemic activities. It has also been shown to induce necroptosis and chromatinolysis in glioma cells.
Shikonin
Product ID S291333
Cas No. 517-89-5
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 517-89-5 |
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| Purity | ≥98% |
| Formula | C16H16O5 |
| Formula Wt. | 288.29 |
| Chemical Name | R(-)-Shikonin |
| IUPAC Name | 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione |
| Synonym | Isoarnebin 4, (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione, (-)-Shikonin |
Shipping and Storage
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Zhao Z, Zhu Q, Zhou X, et al. Structural basis for the inhibition of SARS-CoV-2 Mpro D48N mutant by shikonin and PF-07321332. Viruses. 2023 Dec 30;16(1):65. PMID: 38257765.
Huang B, Wang Q, Jiang L, et al. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Front Pharmacol. 2022 Aug 17;13:926945. PMID: 36059938.
Maeoka R, Ouji Y, Nakazawa T, et al. Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance. Biomed Pharmacother. 2023 Oct;166:115296. PMID: 37557011.
Wang X, Fan L, Wang X, et al. Cyclophilin A contributes to shikonin-induced glioma cell necroptosis and promotion of chromatinolysis. Sci Rep. 2022 Aug 29;12(1):14675. PMID: 36038617.
Xu Z, Huang L, Zhang T, et al. Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3beta signalling. Oncol Lett. 2022 Jul 8;24(3):304. PMID: 35949620.