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n-Octyl caffeate exhibits antioxidative, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. n-Octyl caffeate decreases lipid peroxidation, activity of xanthine oxidase, activation of JNK and ERK, and production of NO and iNOS in rat brain homogenate; it also prevents the LPS-induced drop in mean arterial pressure in aortic smooth muscle cells. In animal models of tumor metastasis, n-octyl caffeate decreases tumor nodules.
| Cas No. | 478392-41-5 |
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| Purity | ≥98% |
| Formula | C17H24O4 |
| Formula Wt. | 292.37 |
| IUPAC Name | Octyl (2E)-3-(3,4-dihydroxyphenyl)acrylate |
| Synonym | Caffeic acid n-octyl ester, 3,4-dihydroxycinnamic acid n-octyl ester. |
| Appearance | White Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nagaoka T, Banskota AH, Tezuka Y, et al. Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-L5 carcinoma cells. Biol Pharm Bull. 2003 May;26(5):638-41. PMID: 12736504.
Hsiao G, Shen MY, Chang WC, et al. A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells. Biochem Pharmacol. 2003 Apr 15;65(8):1383-92. PMID: 12694879.