LKT Labs

Biochemicals for Life Science Research

LXH254

LXH254

Product ID L930280
Cas No. 1800398-38-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $61.00 In stock
5 mg $248.00 In stock
10 mg $441.00 In stock
25 mg $717.00 In stock
Bulk Quote

Quicklinks

Description

LXH254 is a type II RAF inhibitor.

Product Info

Cas No.

1800398-38-2
Purity

≥99%
Formula

C25H25F3N4O4
Formula Wt.

502.49
IUPAC Name

N-[3-[2-(2-hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide
Synonym

Naporafenib
Appearance

White powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

Info Sheet

L930280 Info Sheet PDF

References

Monaco K, Delach S, Yuan J, et al. LXH254, a potent and selective ARAF-sparing inhibitor of BRAF and CRAF for the treatment of MAPK-driven tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073. PMID: 33355204

Park S, Kim T, Cho S, et al. Combined blockade of polo-like kinase and pan-RAF is effective against NRAS-mutant non-small cell lung cancer cells. Cancer Lett. 2020 Dec 28;495:135-144. PMID: 32979462

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • R2815

    Recombinant HIV-1 “0” group consensus

    Recombinant HIV-1 antigen fragment.

    ≥95%
  • S020665

    Saquinavir

    Protease inhibitor

    ≥99%
  • M184774

    5-(Methylsulfinyl)pentyl Nitrile

    Synthetic compound related to sulforaphane.

    ≥98%
  • S1971

    Sertraline Hydrochloride

    FIASMA, SERT and DAT inhibitor, α1-adrenergic ...

    ≥98%
  • C7992

    CTX-0294885

    Bisaniline pyrimidine; pan-kinase inhibitor.

    ≥98%
  • P2515

    3-Phenylpropyl Isothiocyanate

    Synthetic ITC.

    ≥98%
  • P698574

    Prolylrapamycin

    Rapamycin analog
  • H9802

    Hyaluronic Acid Sodium (7-10 kDA)

    Glycosaminoglycan
  • R1879

    Retinyl Palmitate

    Vitamin A derivative, palmitic acid ester of re...

    ≥1.70 MIU/g, bio assay
  • T3468

    Tirapazamine

    Topoisomerase II inhibitor, RPA modulator.

    ≥98%
  • M1644

    Meloxicam

    NSAID; COX-2 inhibitor.

    ≥98%
  • P0256

    Pantoprazole Sodium Sesquihydrate

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%
  • E6234

    Epigallocatechin Gallate

    Flavanol found in Camilla (green tea); AhR ant...

    ≥98%
  • S5868

    Sorafenib

    c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...

    ≥98%
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • B8278

    Butoconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • L2876

    Luteinizing Hormone Releasing Hormone III, lamprey

    Peptide hormone found in eels; GnRH agonist, we...

    ≥98%
  • M1649

    Melanoma-associated Antigen Peptide 1 (27-35), human

    Melanoma-associated antigen.

    ≥95%
  • S1810

    Secnidazole

    Nitroimidazole, binds DNA; nucleic acid synthes...

    ≥98%