• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Fleroxacin

Fleroxacin

Product ID F4518
Cas No. 79660-72-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $117.20 In stock
5 g $260.50 In stock
10 g $416.90 In stock
25 g $867.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fleroxacin is a fluoroquinolone antibiotic that displays antibacterial activity against gram positive and gram negative bacteria. Fleroxacin inhibits bacterial DNA gyrase and helicase. In vitro, fleroxacin inhibits DNA unwinding and ATPase activities of Bloom helicase, stabilizing the enzyme in a low activity conformation, disrupting ATP hydrolysis and blocking helicase translocation on DNA strands. Additionally, fleroxacin
increases reactive oxygen species (ROS) and peroxidation of squalene when exposed to UVA light, indicating phototoxicity in vitro.

Product Info

Cas No.

79660-72-3

Purity

≥98%

Formula

C17H18F3N3O3

Formula Wt.

369.34

Chemical Name

AM-833; Megalocin; Megalone; Quinodis

IUPAC Name

6, 8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline- 3-carboxylic acid

Synonym

AM-833, Megalocin, Megalone, Quinodis

Melting Point

264-266°C

Solubility

Soluble in acid, alkali, not soluble in water

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4518 MSDS PDF

Info Sheet

F4518 Info Sheet PDF

References

Luo H, Xu HQ, Chen X, et al. Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase. Biomed Environ Sci. 2013 Apr;26(4):231-42. PMID: 23534463.

Kawada A, Hatanaka K, Gomi H, et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. Photodermatol Photoimmunol Photomed. 1999 Dec;15(6):226-30. PMID: 10599972

Gocke E. Mechanism of quinolone mutagenicity in bacteria. Mutat Res. 1991 May;248(1):135-43. PMID: 1851537.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1750

    Temocapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • L3455

    α-Linolenic Acid

    An omega-3 fatty acid.

    ≥98%
  • N1980

    Neuromedin B, pig

    Endogenous bombesin-related peptide, involved i...

    ≥95%
  • R2353

    RF-NH2

    RF-amide peptide; potential GPR147 agonist, pot...

    ≥95%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • T6830

    Triadimefon

    Neurotoxin, mutagen.

    ≥98%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • C0153

    Calcitonin, rat

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • T1675

    Teriparatide Acetate

    Synthetic peptide hormone, PTH analog; PTH1R ag...

    ≥95%
  • B465806

    BLU-667

    RET inhibitor.

    ≥98%
  • S0500

    SB-203580

    p38 MAPK inhibitor.

    ≥98%
  • A6800

    AR-A014418

    GSK-3β inhibitor.

    ≥98%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • H0003

    H89

    PKA inhibitor, potential ROCK, S6K1, MSK1, PKB ...

    ≥98%
  • T2932

    Thiamphenicol Glycinate Hydrochloride

    Chloramphenicol derivative; protein translation...

    ≥98%
  • B7118

    Brevetoxin 3 42-carboxylic Acid

    Polyether neurotoxin found in Karenia brevis; N...

    ≥95%
  • H1893

    Hexarelin

    Synthetic ghrelin analog; ghrelin agonist.

    ≥95%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • N5409

    Nocodazole

    Microtubule polymerization inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only