LKT Labs

Biochemicals for Life Science Research

Fleroxacin

Fleroxacin

Product ID F4518
Cas No. 79660-72-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $117.20 In stock
5 g $260.50 In stock
10 g $416.90 In stock
25 g $867.80 In stock
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Description

Fleroxacin is a fluoroquinolone antibiotic that displays antibacterial activity against gram positive and gram negative bacteria. Fleroxacin inhibits bacterial DNA gyrase and helicase. In vitro, fleroxacin inhibits DNA unwinding and ATPase activities of Bloom helicase, stabilizing the enzyme in a low activity conformation, disrupting ATP hydrolysis and blocking helicase translocation on DNA strands. Additionally, fleroxacin
increases reactive oxygen species (ROS) and peroxidation of squalene when exposed to UVA light, indicating phototoxicity in vitro.

Product Info

Cas No.

79660-72-3
Purity

≥98%
Formula

C17H18F3N3O3
Formula Wt.

369.34
Chemical Name

AM-833; Megalocin; Megalone; Quinodis
IUPAC Name

6, 8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline- 3-carboxylic acid
Synonym

AM-833, Megalocin, Megalone, Quinodis
Melting Point

264-266°C
Solubility

Soluble in acid, alkali, not soluble in water
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

F4518 MSDS PDF
Info Sheet

F4518 Info Sheet PDF

References

Luo H, Xu HQ, Chen X, et al. Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase. Biomed Environ Sci. 2013 Apr;26(4):231-42. PMID: 23534463.

Kawada A, Hatanaka K, Gomi H, et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. Photodermatol Photoimmunol Photomed. 1999 Dec;15(6):226-30. PMID: 10599972

Gocke E. Mechanism of quinolone mutagenicity in bacteria. Mutat Res. 1991 May;248(1):135-43. PMID: 1851537.

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