LKT Labs

Biochemicals for Life Science Research

Latrunculin B

Latrunculin B

Product ID L0077
Cas No. 76343-94-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $343.00 In stock
Bulk Quote

Quicklinks

Description

Latrunculin B is a thiazolidinone macrolide found in the Red Sea sponge. Latrunculin acts as an actin inhibitor, binding to G-actin and preventing its transition to F-actin and actin polymerization. This action results in inhibition of rhizoid formation in plants and alterations in Ca2+ trafficking in macrophages. Latrunculin B also exhibits anticancer activity; it induces breaks in double-stranded DNA and increases levels of Bax to induce apoptosis in vitro. Additionally, this compound induces actin microfilament destabilization in prostate cancer cells.

Product Info

Cas No.

76343-94-7
Purity

≥98%
Formula

C20H29NO5S
Formula Wt.

395.51
Chemical Name

(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
IUPAC Name

(4S)-4-[(4Z,8Z,13R,15R)-15-Hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
Synonym

LAT-B, (+)-latrunculin B
Solubility

Ethanol

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

L0077 MSDS PDF
Info Sheet

L0077 Info Sheet PDF

References

Ahn YT, Shin IJ, Kim JM, et al. Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines. Oncol Lett. 2013 Nov;6(5):1383-1389. PMID: 24179529.

Helal MA, Khalifa S, Ahmed S. Differential binding of latrunculins to G-actin: a molecular dynamics study. J Chem Inf Model. 2013 Sep 23;53(9):2369-75. PMID: 23988111.

Kudrimoti S, Ahmed SA, Daga PR, et al. Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity. Bioorg Med Chem. 2009 Nov 1;17(21):7517-22. PMID: 19800245.

Yoshida K, Shimmen T. Involvement of actin filaments in rhizoid morphogenesis of Spirogyra. Physiol Plant. 2009 Jan;135(1):98-107. PMID: 19121103.

Kurilova LS, Krutetskaia ZI, Lebedev OE. Effect of latrunculin B, jasplakinolide and brefeldin A on the store-dependent Ca2+ entry in macrophages. Tsitologiia. 2006;48(10):867-74. PMID: 17162846.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A488240

    AMG-337

    Selective inhibitor of c-Met.

    ≥99%
  • F285081

    Fidaxomicin

    Macrocycle

    ≥98%
  • N1822

    Nefazodone Hydrochloride

    5-HT2 antagonist, SERT and NET inhibitor, hERG ...

    ≥98%
  • H9862

    Hypothemycin

    Polyketide found in Setophoma.

    ≥96%
  • D3420

    4-(3,4-Difluorobenzo)curcumin

    Curcumin derivative.

    ≥95%
  • N3278

    7-Nitroindazole

    nNOS inhibitor.

    ≥98%
  • C9711

    Cyclovirobuxine D

    Found in Buxus; hERG K+ channel inhibitor.

    ≥97%
  • K0117

    Kaempferol

    Flavonol found in various plant sources.

    ≥98%
  • D3200

    Diacetoxyscirpenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • H9801

    Hyaluronic Acid Sodium (~1,000,000)

    Endogenous anionic non-sulfated glycosaminoglyc...
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • C0365

    Carvedilol

    FIASMA; α1- and β1/2-adrenergic antagonist.

    ≥98%
  • R3013

    Recombinant TpN 44.50 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • F5869

    N-formyl-Met-Ala-Ser

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • C0249

    Calcitonin Gene Related Peptide (8-37), rat

    Endogenous calcitonin-family peptide frgament, ...

    ≥95%
  • M1626

    Megestrol Acetate

    Synthetic progestogen, orexigenic.

    ≥98%
  • T5769

    Toremifene Base

    SERM, androgen modulator.

    ≥98%
  • C0148

    Calcitonin, human

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • D1624

    Deflazacort

    Oxazoline; glucocorticoid agonist.

    ≥98%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%