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WY-14643 is a peroxisome proliferator-activated receptor agonist that has been found to upregulate hepatic gene expression in mouse livers. Furthermore, WY-14643 has been shown to improve proteasomal function, prevent NF-kB activation, and decrease oxidative stress in wild-type and adipose triglyceride lipase knockout mice.
| Cas No. | 50892-23-4 |
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| Purity | ≥98% |
| Formula | C14H14ClN3O2S |
| Formula Wt. | 323.80 |
| Chemical Name | 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanylacetic acid |
| IUPAC Name | ({4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}sulfanyl)acetic acid |
| Synonym | Pirinixic Acid, WY14643 |
| Melting Point | 155-157°C |
| Solubility | DMSO (40 mg/ml) |
| Appearance | Off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Szalowska E, Tesfay HA, van Hijum SA, Kersten S. Transcriptomic signatures of peroxisome proliferator-activated receptor (PPAR) in different mouse liver models identify novel aspects of its biology. BMC Genomics. 2014 Dec; 15(1): 1106. PMID: 25511156.
Mussbacher M, Stessel H, Wolkart G, et al. Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice. J Mol Cell Cardiol. 2014 Dec; 77:11-19. PMID: 25285770.