Description
Oxazolidine Cabazitaxel is an impurity in the synthesis of the anti-cancer compound cabazitaxel.
| Product Unit Size | Cost | Quantity | Stock |
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Oxazolidine Cabazitaxel is an impurity in the synthesis of the anti-cancer compound cabazitaxel.
| Cas No. | 1373171-12-0 |
|---|---|
| Purity | ≥95% |
| Formula | C48H61NO14 |
| Formula Wt. | 875.41 |
| IUPAC Name | 5-O-[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-2-benzoyloxy-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-15-yl] 3-O-tert-butyl (4S,5R)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate |
| Synonym | (4S,5R)-2,2-Dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 5-[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl] 3-(1,1-dimethylethyl) ester |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.
Building block
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EGFR inhibitor.
Imidazole; 14-α demethylase inhibitor.
Polypeptide; serine protease inhibitor.
FIASMA, SERT and NET inhibitor, mAChR antagonis...
STING agonist
Mycotoxin that has structural similarity to est...
Taxane synthesis intermediate.
Naturally occuring isothiocyanate found in broc...
GHB agonist, D2/3 antagonist.
Statin; HMG-CoA reductase inhibitor, potential ...
p110α PI3K inhibitor.
p53 activator.
CDK9 inhibitor.
Laminin-derived hexapeptide.
EGFR (WT, T790M) inhibitor.