LKT Labs

Biochemicals for Life Science Research

(−)-Epigallocatechin

Product ID E6233
Cas No. 970-74-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $43.80 In stock
5 mg $157.40 In stock
Bulk Quote

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Description

(-)-Epigallocatechin (EGC) is a flavanol/catechin originally found in Camilla and other plant sources; it exhibits antioxidative, neuromodulatory, antithrombotic/anticoagulant, anticancer, anti-metastatic, and anti-osteoporotic activities. EGC displays agonist activity at cannabinoid 1 (CB1) receptors. In vivo, EGC inhibits platelet aggregation and increases activated partial thromboplastin time. Additionally, EGC inhibits expression of FLT3 and decreases phosphorylation of p38 MAPK, Akt, and STAT5 in acute myelogenous leukemia (AML) cells, suppressing cell proliferation. In breast cancer cells, EGC inhibits cell migration and invasion. This compound also decreases adipocyte formation, suppresses expression of PPARγ, CEBP, and FABP4, and increases osteogenic differentiation in vitro.

Product Info

Cas No.

970-74-1
Purity

≥98%
Formula

C15H14O7
Formula Wt.

306.27
IUPAC Name

(2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
Synonym

(-)-3,3',4',5,5',7-Flavanhexol, Epigallocatechin, Epigallocatechol

Melting Point

208-210°C
Solubility

Soluble in water or alcohol.
Appearance

White Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

E6233 MSDS PDF
Info Sheet

E6233 Info Sheet PDF
Brochures

Green Tea Flyer

Brochures

Natural Products Booklet

References

Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct. 2013 Oct;4(10):1521-5. PMID: 24056410.

Ly BT, Chi HT, Yamagishi M, et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One. 2013 Jun 20;8(6):e66378. PMID: 23840454.

Ko CH, Siu WS, Wong HL, et al. Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. J Agric Food Chem. 2011 Sep 28;59(18):9870-6. PMID: 21877759.

Korte G, Dreiseitel A, Schreier P, et al. Tea catechins' affinity for human cannabinoid receptors. Phytomedicine. 2010 Jan;17(1):19-22. PMID: 19897346.

Kushima Y, Iida K, Nagaoka Y, et al. Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol Pharm Bull. 2009 May;32(5):899-904. PMID: 19420761.

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