α-Endorphin

Name: α-Endorphin
SKU: E5214
Availability: InStock

Product ID E5214

Cas No. 61512-76-3

Purity ≥95%

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Description

α-Endorphin exhibits much of the same properties as β-endorphin, being an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and exhibits immunomodulatory, neuromodulatory, antidepressant, and antinociceptive/analgesic activities. This peptide, like other endogenous opioids, plays a significant role in reward and reinforcement signaling, especially in brain regions such as the ventral tegmental area (VTA) and nucleus accumbens (NAcc). α-Endorphin release is induced during exercise and shows antidepressant activity in clinical studies.

Product Info

Cas No.	61512-76-3
Purity	≥95%
Formula	C₇₇H₁₂₀N₁₈O₂₆S
Formula Wt.	1745.98
IUPAC Name	(4S)-5-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	E5214 MSDS PDF
Info Sheet	E5214 Info Sheet PDF

References

Charbogne P, Kieffer BL, Befort K. 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology. 2014 Jan;76 Pt B:204-17. PMID: 24035914.

Dinas PC, Koutedakis Y, Flouris AD. Effects of exercise and physical activity on depression. Ir J Med Sci. 2011 Jun;180(2):319-25. PMID: 21076975.

Horváth G, Mécs L. Antinociception by endogenous ligands at peripheral level. Ideggyogy Sz. 2011 Mar 30;64(5-6):193-207. PMID: 21688721.

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α-Endorphin

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Description

Product Info

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References

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