• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
1′-S-1′-Acetoxychavicol Acetate

1′-S-1′-Acetoxychavicol Acetate

Product ID A0917
Cas No. 52946-22-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $108.00 Please Inquire
10 mg $204.00 Please Inquire
25 mg $424.50 Please Inquire
100 mg $1,267.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

1’-(S)-1’-Acetoxychavicol acetate (galangal acetate) displays a wide variety of beneficial properties, including antioxidative, anti-obesity, antibacterial, anti-parasitic, chemopreventative, and chemotherapeutic activities. This compound is best known for its ability to inhibit xanthine oxidase, but also activates transient receptor potential cation channel A1 (TRPA1), an ion channel involved in pain and cold signaling. In vitro, 1’-(S)-1’-Acetoxychavicol acetate decreases GPDH activity and downregulates PPARγ, C/EBPα, and phosphorylated AMPK, inhibiting adipogenesis. Additionally, 1’-(S)-1’-Acetoxychavicol acetate decreases visceral fat mass in animal models. 1’-(S)-1’-Acetoxychavicol acetate displays activity against both gram negative and gram positive bacteria in vitro and anti-parasitic activity against Leishmania donovani. In vitro, 1’-(S)-1’-Acetoxychavicol acetate displays chemopreventive activity, inhibiting development of azoxymethane-induced colon carcinogenesis. In vivo, this compound upregulates Nrf2 and induces expression of glutathione and NADPH quinone oxidoreductase 1. 1’-(S)-1’-Acetoxychavicol acetate also increases caspase-3 activity, inducing apoptosis and cell death in cellular models of glioblastoma and oral carcinoma.

Product Info

Cas No.

52946-22-2

Purity

≥98%

Formula

C13H14O4

Formula Wt.

234.25

Chemical Name

[4-[(1S)-1-acetyloxyprop-2-enyl]phenyl] acetate

IUPAC Name

[4-[(1S)-1-acetyloxyprop-2-enyl]phenyl] acetate

Synonym

Galangal acetate,(-); Galangal acetate,(S);

Solubility

Soluble in DMSO (20 mg/mL), ethanol (20 mg/mL), DMF (14 mg/mL). Insoluble in water (racemizes in the presence of moisture)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

A0917 Info Sheet PDF

References

Williams M, Tietzel I, Quick QA. 1'-Acetoxychavicol acetate promotes caspase 3-activated glioblastoma cell death by overcoming enhanced cytokine expression. Oncol Lett. 2013 Jun;5(6):1968-1972. PMID: 23833677.

Ohnishi R, Matsui-Yuasa I, Deguchi Y, et al. 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am J Chin Med. 2012;40(6):1189-204. PMID: 23227791.

In LL, Arshad NM, Ibrahim H, et al. 1'-Acetoxychavicol acetate inhibits growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations. BMC Complement Altern Med. 2012 Oct 9;12:179. PMID: 23043547.

Yaku K, Matsui-Yuasa I, Azuma H, et al. 1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level. Am J Chin Med. 2011;39(4):789-802. PMID: 21721157.

Kaur A, Singh R, Dey CS, et al. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian J Exp Biol. 2010 Mar;48(3):314-7. PMID: 21046987.

Narukawa M, Koizumi K, Iwasaki Y, et al. Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem. 2010;74(8):1694-6. PMID: 20699565

Latha C, Shriram VD, Jahagirdar SS, et al. Antiplasmid activity of 1'-acetoxychavicol acetate from Alpinia galanga against multi-drug resistant bacteria. J Ethnopharmacol. 2009 Jun 25;123(3):522-5. PMID: 19501283.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1749

    Demecolcine

    Used to study embryonic cloning; microtubule po...

    ≥97%
  • C0021

    Cafestol Acetate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • G1200

    GDC-0068

    Akt inhibitor.

    ≥98%
  • P5745

    Polygalic Acid

    Saponin found in Polygala.

    ≥97%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.

    ≥98%
  • M4000

    MK-2206 Monohydrochloride

    Akt inhibitor.

    ≥99%
  • S0400

    SB-431542

    ALK4/5/7 (activin-like) inhibitor, TGF-β inhib...

    ≥98%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • G4480

    Glucagon, human

    Endogenous peptide hormone, counteracts insulin...

    ≥95%
  • G0096

    GAY

    Tripeptide, used to tag proteins.

    ≥95%
  • T1010

    7-Acetyl Paclitaxel

    Synthesis impurity

    ≥98%
  • G7232

    GS-9973

    Syk inhibitor.

    ≥98%
  • S6130

    Sphingosine-1-Phosphate

    Endogenous sphingolipid involved in cell signal...

    ≥98%
  • O9210

    Oxcarbazepine

    α4β2 nAChR desensitizer, delayed-rectifier vo...

    ≥98%
  • I7458

    1-Isothiocyanato-9-(methylsulfinyl)-nonane

    ITC, sulforaphane analog.

    ≥98%
  • C1620

    Ceftiofur Hydrochloride

    β-lactam; penicillin binding protein inhibitor...

    ≥90%
  • T7037

    Triptorelin Acetate

    Peptide, GnRH analog.

    ≥95%
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • V174459

    Velpatasvir

    Inhibits NS5A

    ≥99%
  • S8049

    S-Sulforaphene

    Isothiocyanate found in cruciferous vegetables....

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only