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2’,3’-Dideoxyinosine is a purine (guanosine) nucleoside analog that exhibits antiviral activity through the direct inhibition of reverse transcriptase. 2’,3’-Dideoxyinosine acts as a chain terminator and is one component of highly active antiretroviral therapy (HAART) regimens used in the treatment of HIV and AIDS. 2’,3’-Dideoxyinosine also inhibits the humoral immune response in vivo, targeting B lymphocytes.
| Cas No. | 69655-05-6 |
|---|---|
| Purity | ≥98% |
| Formula | C10H12N4O3 |
| Formula Wt. | 236.23 |
| Chemical Name | 2',3'-Dideoxyinosine |
| IUPAC Name | 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one |
| Synonym | Didanosine, Dideoxyinosine, ddI, ddIno, Videx |
| Melting Point | 160-163°C |
| Solubility | Soluble in DMSO, polyethylene glycol. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet | |
| Brochures |
Ribera E, Tuset M, Martín M, et al. Characteristics of antiretroviral drugs. Enferm Infecc Microbiol Clin. 2011 May;29(5):362-91. PMID: 21531048.
Phillips KE, Munson AE. 2'3'-Dideoxyinosine inhibits the humoral immune response in female B6C3F1 mice by targeting the B lymphocyte. Toxicol Appl Pharmacol. 1997 Aug;145(2):260-7. PMID: 9266798.
