Description
2′,7-bis(triethylsilyl)taxol is an intermediate in the synthesis of the anti-cancer therapeutic, taxol (paclitaxel) and its derivatives.
2′,7-bis(triethylsilyl)taxol
Product ID T0120
Cas No. 135365-62-7
Purity ≥98%
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Product Info
| Cas No. | 135365-62-7 |
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| Purity | ≥98% |
| Formula | C59H79NO14Si2 |
| Formula Wt. | 1082.44 |
| Chemical Name | 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate] |
| IUPAC Name | (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-1-hydroxy-9-oxo-7-[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate |
| Synonym | 2',7-di-TES-paclitaxel, (2'R,3'S)-2',7-(bis)triethylsilyl taxol; 2’,7-bis(triethylsilyl)Paclitaxel |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
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References
Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.
Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.
Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.
Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.
Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.