Description
Desmethyl VS5584 Is an intermediate in the synthesis of purine analogs and potential tyrosine kinase inhibitor. This analog is a highly selective PI3K/mTOR kinase inhibitor.
5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine
Product ID I0010
Cas No. 1246535-95-4
Purity ≥98%
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Product Info
| Cas No. | 1246535-95-4 |
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| Purity | ≥98% |
| Formula | C16H20N8O |
| Formula Wt. | 340.39 |
| IUPAC Name | 5-[9-Isopropyl-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine |
| Synonym | Desmethyl-VS-5584, Desmethyl VS5584, Desmethyl VS 5584, VS-5584 Analog |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Zhou C, Li X, He A, et al. Development of a UPLC-MS/MS method for the quantification of VS-5584 and its application in pharmacokinetic studies in rats. J Anal Methods Chem. 2020 Dec 16;2020:8811522. PMID: 33381351.
Chen Y, Tsai H, Tsai Y, et al. VS-5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo. J Pediatr Surg. 2021 Aug;56(8):1441-1448. PMID: 33189297.
Xu M, Xu L, Wang Y, et al. BRD4 inhibition sensitizes renal cell carcinoma cells to the PI3K/mTOR dual inhibitor VS-5584. Aging (Albany NY). 2020 Oct 13;12(19):19147-19158. PMID: 33051401.