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A-769662

A-769662

Product ID A2420
Cas No. 844499-71-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $131.80 In stock
10 mg $202.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

A-769662 is an activator of AMPK that is used in research models to study signaling mechanisms involved in cellular homeostasis. A-769662 exhibits anticancer and antithrombotic activities. In prostate cancer cells, this compound inhibits cellular proliferation, migration, and invasion. In osteoblasts, A-769662 inhibits H202-induced apoptosis and decreases accumulation of ROS. Additionally, it also decreases platelet aggregation in vitro.

Product Info

Cas No.

844499-71-4

Purity

≥98%

Formula

C20H12N2O3S

Formula Wt.

360.39

IUPAC Name

4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile

Solubility

DMSO 72 mg/mL (199.78 mM) Water Insoluble Ethanol Insoluble

Appearance

Grey-tan powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A2420 MSDS PDF

Info Sheet

A2420 Info Sheet PDF

References

Kim J, Shin J, Ha J. Screening methods for AMP-activated protein kinase modulators: a patent review. Expert Opin Ther Pat. 2015 Mar;25(3):261-77. PMID: 25535089.

Choudhury Y, Yang Z, Ahmad I, et al. AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience. 2014 Jun 4;1(6):446-56. PMID: 25594043.

Zhu Y, Zhou J, Ao R, et al. A-769662 protects osteoblasts from hydrogen dioxide-induced apoptosis through activating of AMP-activated protein kinase (AMPK). Int J Mol Sci. 2014 Jun 23;15(6):11190-203. PMID: 24960362.

Liu Y, Oh SJ, Chang KH, et al. Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole. Biochem Pharmacol. 2013 Oct 1;86(7):914-25. PMID: 23876340.

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