LKT Labs

Biochemicals for Life Science Research

Acalabrutinib

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
25 mg $307.00 In stock
100 mg $886.00 In stock
Bulk Quote

Quicklinks

Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL.

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1995

    Dexrazoxane Hydrochloride

    Iron chelator.

    ≥98%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • R3312

    Ridaifen A Dihydrochloride

    Tamoxifen derivative; potential proteasome inhi...

    ≥98%
  • C0248

    Calcineurin Substrate

    Peptide used to measure in vitro calcineurin ac...

    ≥96%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • S6130

    Sphingosine-1-Phosphate

    Endogenous sphingolipid involved in cell signal...

    ≥98%
  • D0010

    3H-1,2-Dithiole-3-thione

    Induces activation of Nrf2; inhibits apoptosis ...

    ≥98%
  • D004098

    Dacomitinib Anhydrous

    EGFR inhibitor.

    ≥99%
  • E5178

    Emtricitabine

    Nucleoside (cytidine) analog; RT and telomerase...

    ≥98%
  • D3261

    Dipropyl Disulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%
  • C5680

    Coumestrol

    Phytoestrogen found in various plant sources; E...

    ≥97%
  • J0240

    JAK2 Inhibitor V

    JAK2 inhibitor.

    ≥98%
  • U698574

    Urolithin A

    Ellagic acid derivative produced by gut microfl...

    ≥98%
  • A9601

    AZD-5363

    AKT inhibitor, potential ROCK, p70S6K, PKA, MKK...

    ≥99%, ≥99%ee
  • A5234

    Amisulpride

    5-HT7 and D2/3 antagonist.

    ≥98%
  • E499601

    Empagliflozin

    SGLT2 inhibitor

    ≥98%
  • P3600

    PJ34 Hydrochloride

    PARP inhibitor; potential Pim1 inhibitor.

    ≥95%
  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and P...

    ≥98%
  • J5237

    JNJ-26854165

    MDM2 inhibitor.

    ≥98%