LKT Labs

Biochemicals for Life Science Research

Acalabrutinib

Acalabrutinib

Product ID A081014
Cas No. 1420477-60-6
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $115.90 In stock
25 mg $306.70 In stock
100 mg $885.80 In stock
Bulk Quote

Quicklinks

Description

Acalabrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK). It showed increased selectivity compared with first generation BTK inhibitors such as ibrutinib while offering similar antitumor efficacy in mouse models of chronic lymphocytic leukemia. It has been approved for the treatment of patients with relapsed mantle cell lymphoma(MCL), a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. It is currently being investigated as a front line treatment for MCL.

Product Info

Cas No.

1420477-60-6
Purity

≥99%
Formula

C26H23N7O2
Formula Wt.

465.52
IUPAC Name

4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
Synonym

ACP-196

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A081014 MSDS PDF
Info Sheet

A081014 Info Sheet PDF

References

Herman S., Montraveta A., et al. The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia. Clin Cancer Res. 23(11):2831-41 (2016). PMID:27903679.

Witzig T., Inwards D. Acalabrutinib for mantle cell lymphoma. Blood. 133(24):2570-74 (2019). PMID: 30967367.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V1869

    Verbascoside

    Phenylpropanoid found in Castilleja, Verbena, V...

    ≥98%
  • B6805

    Bradykinin (1-7)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • H9812

    5-Hydroxytryptophol

    Serotonin/melatonin analog found in various pla...

    ≥98%
  • Z5645

    Zoledronate Disodium Tetrahydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • G0668

    GBR 12935 Dihydrochloride

    DAT inhibitor.

    ≥98%
  • R1724

    Regadenoson

    Adenosine A2A agonist.

    ≥99%
  • G3459

    Ginsenoside Rg2

    Triterpene saponin found in species of Panax.

    ≥98%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • G7345

    GSK-2606414

    PERK inhibitor.

    ≥99%
  • B1955

    Benztropine Mesylate

    DAT inhibitor.

    ≥99%
  • U6857

    Urodilatin CCC

    ANP fragment, natriuretic peptide; Na+/K+ ATPas...

    ≥98%
  • G3456

    Ginsenoside Rd

    Triterpene saponin found in species of Panax; 2...

    ≥98%
  • E7579

    Estramustine Phosphate Disodium

    Nitrogen mustard and estradiol derivative; micr...

    ≥95%
  • T1673

    Terlipressin Acetate

    Synthetic peptide, vasopressin analog; AVPR1 ag...

    ≥95%
  • O486179

    Omeprazole Impurity C

    Impurity of omeprazole

    ≥99%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • A5279

    Angiotensin II (1-4), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • T982698

    L-Tyrosine disodium salt

    Amino acid precursor of dopamine.

    ≥98%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • I7341

    Isoniazid

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%