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Adefovir Dipivoxil

Adefovir Dipivoxil

Product ID A1218
Cas No. 142340-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $71.50 In stock
50 mg $204.30 In stock
250 mg $612.70 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Adefovir dipivoxil is the diester form of adefovir, an antiviral prodrug that displays immunomodulatory activity. Adefovir is an acyclonucleotide analog that inhibits viral DNA polymerase, acting as a DNA chain terminator. Adefovir is primarily used to treat hepatitis B infection, but also displays activity against retroviruses. Adefovir decreases levels of Treg cells and increases levels of IL-4, IL-2, TNF-α, and IFN-γ. Additionally, this compound may show anti-arthritic activity as well, inhibiting production of NO and expression of RANTES and acting both as a prophylactic or a rescue treatment in animal models of adjuvant-induced arthritis.

Product Info

Cas No.

142340-99-6

Purity

≥98%

Formula

C20H32N5O8P

Formula Wt.

501.47

Chemical Name

[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

IUPAC Name

[2-(6-aminopurin-9-yl)ethoxymethyl-(2, 2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

Synonym

Hepsera, Preveon

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A1218 MSDS PDF

Info Sheet

A1218 Info Sheet PDF

References

Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

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