LKT Labs

Biochemicals for Life Science Research

Adefovir Dipivoxil

Product ID A1218
Cas No. 142340-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $55.10 In stock
50 mg $157.40 In stock
250 mg $472.00 In stock
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Description

Adefovir dipivoxil is the diester form of adefovir, an antiviral prodrug that displays immunomodulatory activity. Adefovir is an acyclonucleotide analog that inhibits viral DNA polymerase, acting as a DNA chain terminator. Adefovir is primarily used to treat hepatitis B infection, but also displays activity against retroviruses. Adefovir decreases levels of Treg cells and increases levels of IL-4, IL-2, TNF-α, and IFN-γ. Additionally, this compound may show anti-arthritic activity as well, inhibiting production of NO and expression of RANTES and acting both as a prophylactic or a rescue treatment in animal models of adjuvant-induced arthritis.

Product Info

Cas No.

142340-99-6
Purity

≥98%
Formula

C20H32N5O8P
Formula Wt.

501.47
Chemical Name

[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
IUPAC Name

[2-(6-aminopurin-9-yl)ethoxymethyl-(2, 2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
Synonym

Hepsera, Preveon
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A1218 MSDS PDF
Info Sheet

A1218 Info Sheet PDF

References

Jiang Y, Li W, Yu L, et al. Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies. Cell Mol Immunol. 2011 Jan;8(1):75-82. PMID: 20921939

Rodriguez-Frias F, Jardi R, Schaper M, et al. Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antivir Ther. 2008;13(8):991-9. PMID: 19195324.

Zídek Z, Franková D, Holý A. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100. PMID: 10440094.

Neyts J, De Clercq E. Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem Pharmacol. 1994 Jan 13;47(1):39-41. PMID: 8311844.

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