Name: Adrenocorticotropic Hormone (1-16), human
SKU: A0966
Availability: InStock

Description

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory activities. ACTH decreases inflammatory cytokine levels and modulates lymphocyte and macrophage functions. In vitro, ACTH stimulates proliferation of osteoblasts and increases mRNA levels of collagen I.

Product Info

Cas No.	5576-42-1
Purity	≥95%
Formula	C₈₉H₁₃₃N₂₅O₂₂S
Formula Wt.	1937.27
Synonym	ACTH (1-16)
Solubility	Soluble in water.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	A0966 Info Sheet PDF

References

Berkovich R, Agius MA. Mechanisms of action of ACTH in the management of relapsing forms of multiple sclerosis. Ther Adv Neurol Disord. 2014 Mar;7(2):83-96. PMID: 24587825.

Isales CM, Zaidi M, Blair HC. ACTH is a novel regulator of bone mass. Ann N Y Acad Sci. 2010 Mar;1192:110-6. PMID: 20392225.

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Adrenocorticotropic Hormone (1-16), human

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