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AK-1 is an inhibitor of sirtuin 2 (SIRT2); sirtuins are considered class III histone deacetylases (HDACs). AK-1 exhibits neuroprotective and anticancer activities. This compound prevents some hippocampal neurodegeneration in animal models of Alzheimer’s disease. AK-1 also induces cell cycle arrest in colon carcinoma cells by downregulating expression of Snail.
| Cas No. | 330461-64-8 |
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| Purity | ≥99% |
| Formula | C19H21N3O5S |
| Formula Wt. | 403.45 |
| IUPAC Name | 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide |
| Synonym | SIRT2 inhibitor II |
| Solubility | Soluble in DMSO |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Cheon MG, Kim W, Choi M, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. PMID: 25312940.
Spires-Jones TL, Fox LM, Rozkalne A, et al. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Front Pharmacol. 2012 Mar 12;3:42. PMID: 22416232.