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AM251

AM251

Product ID A480000
Cas No. 183232-66-8
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $79.10 In stock
25 mg $279.40 In stock
100 mg $988.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AM251 is a cannabinoid receptor 1 (CB1) antagonist/inverse agonist. It works by inhibiting the action of the endocannabinoid system. AM251 shows beneficial effects as an anti-obesity compound. AM251 is renal-protective in rats fed a high-fat diet. Also, AM251 decreases expression of estrogen-related receptor alpha (EER α), a potential therapeutic target for obesity. AM251 also show beneficial effects for the impairment of fear memory in rats.

Product Info

Cas No.

183232-66-8

Purity

≥97%

Formula

C22H21Cl2IN4O

Formula Wt.

555.24

Chemical Name

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

IUPAC Name

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide

Synonym

AM-251, AM 251

Solubility

25mM in ethanol 100mM in DMSO

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A480000 MSDS PDF

Info Sheet

A480000 Info Sheet PDF

References

Krzysik-Walker SM, Gonzalez-Mariscal I, Scheibye-Knudsen M, et al. The Biarylpyrazole Compound AM251 Alters Mitochondrial Physiology via Proteolytic Degradation of ERRalpha. Mol. Pharm. 2013. 83:157-166. PMID: 23066093.

Ratano P, Everitt BJ and Milton AL. The CB1 Receptor Antagonis AM251 Impairs Reconsolidation of Pavlovian Fear Memory in the Rat Basolateral Amygdala. Neuropsychopharmoacology. 2014 Oct;39(11):2529-37. PMID: 24801769.

Jenkin KA, O’Keefe L, Simcocks AC, et al. Chronic administration of AM251 improves albuminuria and renal tubular structure in obese rats. J Endocrin. 2015 May;225(2)113-24. PMID: 25804605.

Custom Order

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