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Amorolfine is an antifungal compound that prevents ergosterol synthesis through the inhibition of sterol 14α-demethylase. Amorolfine increases release of prostaglandin D2 metabolites, inhibiting release of thromboxane B2 (TxB2), activation of NF-κB, and production of thymic stromal lymphopoietin; as a result, inflammation in atopic dermatitis models is decreased.
| Cas No. | 78613-38-4 |
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| Purity | ≥98.5% |
| Formula | C21H35NO • HCl |
| Formula Wt. | 353.97 |
| Chemical Name | (2S,6R)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine hydrochloride |
| IUPAC Name | (2R,6S)-2, 6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl] morpholine;hydrochloride |
| Melting Point | 204-206°C |
| Solubility | Slightly soluble in water, less soluble in HCl solution |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ghelardi E, Celandroni F, Gueye SA, et al. Potential of Ergosterol Synthesis Inhibitors To Cause Resistance or Cross-Resistance in Trichophyton rubrum. Antimicrob Agents Chemother. 2014 May;58(5):2825-9. PMID: 24614379.
Hau CS, Kanda N, Watanabe S. Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. J Dermatol Sci. 2013 Sep;71(3):174-83. PMID: 23688403.