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Ampalex is a benzylpiperidine AMPA receptor potentiator. It exhibits antipsychotic activity and may also show cognition enhancing and neuroprotective benefits. Ampalex modulates fast synaptic plasticity and memory process in various models. This compound also improves cognitive function in animal models of schizophrenia.
| Cas No. | 154235-83-3 |
|---|---|
| Purity | ≥98% |
| Formula | C14H15N3O |
| Formula Wt. | 241.29 |
| IUPAC Name | 1-Piperidinyl(6-quinoxalinyl)methanone |
| Synonym | CX-516, BDP-12, Benzoyl-Piperidine-12, SPD-420 |
| Solubility | H2O: 5 mg/mL DMSO 40 mg/ml |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. PMID: 17504104.
Olsen CK, Kreilgaard M, Didriksen M. Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacol Biochem Behav. 2006 Jun;84(2):259-65. PMID: 16782180.
O'Neill MJ, Bleakman D, Zimmerman DM, et al. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. PMID: 15180479.
Danysz W. CX-516 (Cortex Pharmaceuticals Inc). IDrugs. 1999 Aug;2(8):814-22. PMID: 16127658.