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Amrinone

Amrinone

Product ID A5170
Cas No. 60719-84-8
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $92.00 In stock
1 g $265.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Amrinone is a pyridine phosphodiesterase 3 (PDE 3) inhibitor that is clinically used to treat congestive heart failure (CHF). Amrinone may be administered during cardiopulmonary bypass surgery. Amrinone exhibits positive inotropic activity, inducing vasodilation and increasing cardiac contractility through alterations in cAMP and Ca2+ signaling.

Product Info

Cas No.

60719-84-8

Purity

≥98%

Formula

C10H9N3O

Formula Wt.

187.20

Chemical Name

5-Amino-(3,4'-bipyridin)-6(1H)-one

IUPAC Name

3-amino-5-pyridin-4-yl-1H-pyridin-2-one

Synonym

Cartonic, Inocor, Vesistol, Wincoram

Melting Point

294-297°C(dec.)

Solubility

Insoluble in water. Slightly soluble in hot acetic acid and dimethylformamide. Soluble in dilute inorganic acids.

Appearance

Yellow to light yellow crystalline Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A5170 MSDS PDF

Info Sheet

A5170 Info Sheet PDF

References

Coons JC, McGraw M, Murali S. Pharmacotherapy for acute heart failure syndromes. Am J Health Syst Pharm. 2011 Jan 1;68(1):21-35. PMID: 21164062.

van der Zypp A, Rechtman M, Majewski H. The role of cyclic nucleotides and calcium in the relaxation produced by amrinone in rat aorta. Gen Pharmacol. 2000 Apr;34(4):245-53. PMID: 11282218.

Hamada Y, Kawachi K, Yamamoto T, et al. Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone. Jpn Circ J. 1999 Aug;63(8):605-9. PMID: 10478810.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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