• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Anisomycin

Anisomycin

Product ID A5373
Cas No. 22862-76-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $44.20 In stock
25 mg $82.00 In stock
100 mg $212.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Anisomycin is an antibiotic initially produced by Streptomyces that retains no antibacterial activity. Anisomycin exhibits neuromodulatory and anticancer chemotherapeutic activities. Anisomycin inhibits peptidyl transferase in the 80S ribosome, suppressing protein synthesis. In animal models, anisomycin decreases facilitation of fear conditioning pre-shock; it also inhibits consolidation and reconsolidation in incentive learning models. Anisomycin induces apoptosis and inhibits cell proliferation in breast cancer cells. Anisomycin also inhibits growth of Ehrlich ascites carcinoma cells in vitro and in vivo, inducing caspase-dependent apoptosis and DNA strand breakage. Additionally, this compound inhibits expression of CDK2 and activates p53, p21, and p27, inducing cell cycle arrest and inhibiting cell proliferation in Jurkat T cells.

Product Info

Cas No.

22862-76-6

Purity

≥98%

Formula

C14H19NO4

Formula Wt.

265.31

Chemical Name

1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate

IUPAC Name

[(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate

Synonym

Flagecidin

Melting Point

140-141°C

Solubility

Moderately soluble in water; sol in lower alcohols, esters or ketones.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A5373 MSDS PDF

Info Sheet

A5373 Info Sheet PDF

References

Monaghan D, O'Connell E, Cruickshank FL, et al. Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues. Biochem Biophys Res Commun. 2014 Jan 10;443(2):761-7. PMID: 24333448.

Yu C, Xing F, Tang Z, et al. Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins. Pharmacol Rep. 2013;65(2):435-44. PMID: 23744428.

You P, Xing F, Huo J, et al. In vitro and in vivo evaluation of anisomycin against Ehrlich ascites carcinoma. Oncol Rep. 2013 Jun;29(6):2227-36. PMID: 23525555.

Wang SH, Ostlund SB, Nader K, et al. Consolidation and reconsolidation of incentive learning in the amygdala. J Neurosci. 2005 Jan 26;25(4):830-5. PMID: 15673662.

Barrientos RM, O'Reilly RC, Rudy JW. Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. Behav Brain Res. 2002 Aug 21;134(1-2):299-306. PMID: 12191817.

Grollman AP. Inhibitors of protein biosynthesis. II. Mode of action of anisomycin. J Biol Chem. 1967 Jul 10;242(13):3226-33. PMID: 6027796.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5225

    α-ANP (1-28), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • P5885

    Povidone Iodine

    Polyvinyl pyrrolidone polymer, disinfectant.

    ≥98%
  • C9779

    Cytisine

    Alkaloid found in Fabaceae family plants; α3β...

    ≥98%
  • S3584

    Sivelestat Sodium Tetrahydrate

    Neutrophil elastase inhibitor.

    ≥99%
  • A7071

    Atriopeptin II, rat/rabbit/mouse

    ANP analog, cardiomodulatory peptide; NPR-A ago...

    ≥95%
  • A225822

    Afuresertib

    Inhibitor of Akt.

    ≥98%
  • T0107

    Xylosyltaxol C

    Taxane found in species of Taxus; potential mic...

    ≥90%
  • G0250

    cGAMP Disodium [STING Ligand]

    Cyclic dinucleotide that detects cytosolic DNA ...

    ≥98%
  • P3463

    Piperacillin Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • G0152

    Ganciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • O783720

    OTS-964

    Inhibitor of T-lymphokine-activated killer cell...

    ≥98%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • T0205

    3”,4”-Dehydropaclitaxel C

    Semi-synthetic taxane.

    ≥95%
  • F5868

    Formoterol Fumarate Dihydrate

    β2-adrenergic agonist.

    ≥98%
  • I7259

    Isoproterenol Hydrochloride

    β-adrenergic agonist.

    ≥98%
  • P1635

    Peiminine

    Steroidal alkaloid found in Fritillaria; M2 mAC...

    ≥98%
  • P014442

    Palbociclib

    CDK4/6 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only