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Aphidicolin is a diterpene antibiotic initially produced by Cephalosporum that exhibits antiviral activities. Aphidicolin inhibits eukaryotic DNA replication by inhibiting DNA polymerase and inducing S phase cell cycle arrest. In research models, aphidicolin is used to study cell cycle phases. This compound also inhibits the growth of vaccinia virus in vivo by inhibiting viral DNA polymerase.
| Cas No. | 38966-21-1 |
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| Purity | ≥98% |
| Formula | C20H34O4 |
| Formula Wt. | 338.48 |
| Chemical Name | (3α,4α,5α,17α)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol |
| IUPAC Name | (1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol |
| Synonym | ICI-69653, NSC-234714 |
| Melting Point | 227-232°C |
| Solubility | Soluble in DMSO, ethanol. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Willis J, DeStephanis D, Patel Y, et al. Study of the DNA damage checkpoint using Xenopus egg extracts. J Vis Exp. 2012 Nov 5;(69):e4449. PMID: 23149695.
Zhao YM, Li JY, Lan JP, et al. Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2008 May 16;369(4):1114-9. PMID: 8339310.
DeFilippes FM. Effect of aphidicolin on vaccinia virus: isolation of an aphidicolin-resistant mutant. J Virol. 1984 Nov;52(2):474-82. PMID: 6436508.