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Aristolochic acid A is a carcinogenic compound found in Aristolochia and Radix that has commonly been used in traditional Chinese medicine. This compound inhibits phospholipase A2 (PLA2) and decreases GABA-induced release of arachidonic acid and phosphatidylcholine as well as exocytosis in vitro.
| Cas No. | 313-67-7 |
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| Purity | ≥95% |
| Formula | C17H11NO7 |
| Formula Wt. | 341.27 |
| Chemical Name | 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid |
| IUPAC Name | 8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid |
| Synonym | Aristolochic acid, Aristolochin Birthwort, Tardolyt |
| Melting Point | 281-286°C(dec.) |
| Solubility | Soluble in DMSO or ethanol. |
| Appearance | Yellow Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Chen WY, Ni Y, Pan YM, et al. GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa. FEBS Lett. 2005 Aug 29;579(21):4692-700. PMID: 16098515.
Stiborová M, Frei E, Sopko B, et al. Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase. Carcinogenesis. 2003 Oct;24(10):1695-703. PMID: 12869422.