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AZD-2014 is an inhibitor of mTORC1/2 that exhibits anticancer chemotherapeutic activity. AZD-2014 induces autophagy and inhibits growth without causing apoptosis in colorectal cancer cells. In animal models, AZD-2014 inhibits tumor growth of colorectal cancer xenografts.
| Cas No. | 1009298-59-2 |
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| Purity | ≥98% |
| Formula | C25H30N6O3 |
| Formula Wt. | 462.54 |
| IUPAC Name | 3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide |
| Synonym | Vistusertib |
| Solubility | DMSO 38 mg/mL (82.15 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Yellow Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet | |
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Huo HZ, Zhou ZY, Wang B, et al. Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. Biochem Biophys Res Commun. 2014 Jan 10;443(2):406-12. PMID: 24309100.