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Baloxavir Marboxil

Baloxavir Marboxil

Product ID B011460
Cas No. 1985606-14-1
Purity ≥ 99%
Product Unit SizeCostQuantityStock
5 mg $47.30 In stock
5 mg $47.30 In stock
5 mg $47.30 In stock
25 mg $78.80 In stock
100 mg $131.30 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. It has also been investigated for its potential to treat COVID-19 but no proven benefit has been observed.

Product Info

Cas No.

1985606-14-1

Purity

≥ 99%

Formula

C27H23F2N3O7S

Formula Wt.

571.6

Chemical Name

(((12aR)-12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-6,8-dioxo-3,4,6,8,12,12ahexahydro-1H-(1,4)oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazin-7-yl)oxy)methyl methyl carbonate

IUPAC Name

[(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-yl]oxymethyl methyl carbonate

Synonym

Xofluza, , S-033188

Solubility

DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B011460 MSDS PDF

Info Sheet

B011460 Info Sheet PDF

References

Checkmahomed L, Padey B, Pizzorno A, et al. In vitro combinations of baloxavir acid and other inhibitors against seasonal influenza A viruses. Viruses. 2020 Oct 8;12(10):1139. PMID: 33049959.

Lou Y, Yao H, Hu X, et al. Clinical outcomes and plasma concentrations of baloxavir marboxil and favipiravir in COVID-19 patients: an exploratory randomized, controlled trial. Eur J Pharm Sci. 2020 Oct 25;105631. PMID: 33115675.

Janabi A. Effective anit-SARS-CoV-2 RNA dependent RNA polymerase drugs based on docking methods: the case of milbemycin, ivermectin, and baloxavir marboxil. Avicenna J Med Biotechnol. 2020 Oct-Dec;12(4):246-250. PMID: 33014317.

Saito R, Osada H, Wagatsuma K, et al. Duration of fever and symptoms in children after treatment with baloxavir marboxil and oseltamivir during the 2018-2019 season and detection of variant influenza A viruses with polymerase acidic subunit substitutions. Antiviral Res. 2020 Nov;183:104951. PMID: 32987032.

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