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Benidipine Hydrochloride

Benidipine Hydrochloride

Product ID B1752
Cas No. 91599-74-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $47.30 In stock
25 mg $78.80 In stock
100 mg $183.80 In stock
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
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Description

Benidipine is a long-lasting dihydropyridine calcium channel blocker. Its antihypertensive activity involves the inhibition of Ca(2+) influx through L-type voltage dependent calcium channels and the ability to restore endothelial function. It prevents lysoPC-induced caspase-3 activation through stimulation of NO release thereby exerts its anti-apoptosis action on endothelial cells. Benidipine increases the maximal activity of ERK1/2 but has no significant effect on p38 MAPK, decreases mitochondrial cytochrome c release, and reduces caspase-9 activation.

Benidipine was shown to have antioxidant effect in reducing hydroxyl radicals formation and PKC-dependent NO production. It inhibits [3H]thymidine incorporation into vascular smooth muscle cells (VSMCs), an indication of its anti-proliferative effects which may be useful for the treatment of restenosis following angioplasty and atherosclerosis damages.

Product Info

Cas No.

91599-74-5

Purity

≥98%

Formula

C28H31N3O6 ・HCl

Formula Wt.

542.03

Chemical Name

5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

IUPAC Name

(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

Synonym

KW-3049

Solubility

DMSO Solubility: 8 mg/mL (14.75 mM)

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1752 MSDS PDF

Info Sheet

B1752 Info Sheet PDF

References

Matsubara M , Yao K, Hasegawa K. Benidipine, a dihydropyridine-calcium channel blocker, inhibits
lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release.Pharmacol Res. 2006 Jan;53(1):35-43. PMID: 16172001.

Wang N , Minatoguchi S, Chen XH, et al.
Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits. J Cardiovasc Pharmacol. 2004 Jun;43(6):747-57. PMID: 15167267.

Ide S , Kondoh M, Satoh H, Karasawa A. Anti-proliferative effects of benidipine hydrochloride in porcine cultured
vascular smooth muscle cells and in rats subjected to balloon catheterinduced endothelial denudation.Biol Pharm Bull. 1994 May;17(5):627-31. PMID: 7920421.

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