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BMS-911543

BMS-911543

Product ID B5000
Cas No. 1271022-90-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $142.80 In stock
5 mg $375.60 In stock
25 mg $1,021.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

BMS-911543 is an oral selective inhibitor of JAK2 currently in clinical trials. BMS-911543 shows anticancer activity through inhibition of the JAK/STAT signaling cascade in in vitro and in vivo models of myeloproliferative neoplasms, which display constitutively active JAK2 signaling. This compound exhibits antiproliferative and anti-erythropoetic effects.

Product Info

Cas No.

1271022-90-2

Purity

≥99%

Formula

C23H28N8O

Formula Wt.

432.52

IUPAC Name

N,N-dicyclopropyl-7-[(1,5-dimethylpyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide

Synonym

BMS911543

Solubility

DMSO 36 mg/mL (83.23 mM) Ethanol 22 mg/mL (50.86 mM) Water Insoluble

Appearance

Off-White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B5000 MSDS PDF

Info Sheet

B5000 Info Sheet PDF

Brochures

JAK/STAT Flyer

References

Purandare AV, McDevitt TM, Wan H, et al. Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. Leukemia. 2012 Feb;26(2):280-8. PMID: 22015772.

Tibes R, Bogenberger JM, Geyer HL, et al. JAK2 inhibitors in the treatment of myeloproliferative neoplasms. Expert Opin Investig Drugs. 2012 Dec;21(12):1755-74. PMID: 22991927.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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