Description
Boceprevir is an antiviral bioactive small molecule. Found to inhibit Mpro activity and SARS-CoV-2 in Vero cells.
Boceprevir
Product ID B564086
Cas No. 394730-60-0
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
|---|
Product Info
| Cas No. | 394730-60-0 |
|---|---|
| Purity | ≥98% |
| Formula | C27H45N5O5 |
| Formula Wt. | 519.69 |
| Chemical Name | (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| IUPAC Name | (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| Synonym | Victrelis, SCH 503034, EBP 520 |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
References
Fu L, Ye F, Feng Y, et al. Both boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun. 2020 Sep 4;11(1):4417. PMID: 32887884.
Oerlemans R, Ruiz-Moreno A, Cong Y, et al. Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics. RSC Med Chem. 2021 Mar 1;12(3):370-379. PMID: 34041486.
Ma C, Sacco M, Hurst B, et al. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. 2020 Aug;30(8):678-692. PMID: 32541865.