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C-peptide is an endogenous peptide that connects the A and B chains of insulin in the proinsulin form. C-peptide binds cell surfaces, activating Ca2+-dependent signaling pathways. In animal models of diabetes, C-peptide improves Na+/K+ ATPase activity, improving neuropathy symptoms, and prevents glomerular pathology, improving kidney function.
| Purity | ≥95% |
|---|---|
| Formula | C129H211N35O48 |
| Formula Wt. | 3020.33 |
| Synonym | C-Peptide (57-87), human |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.
Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.
Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.