• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Canertinib Dihydrochloride

Canertinib Dihydrochloride

Product ID C0252
Cas No. 289499-45-2
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $134.70 Please Inquire
100 mg $404.30 In stock
250 mg $808.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Canertinib is an irreversible inhibitor of EGFR (HER2/ErbB). This compound is currently in clinical trials as an anticancer chemotherapeutic, displaying activity against a variety of cancers. In a cellular model of melanoma, canertinib exhibits cytostatic activity, stopping cell growth in the G1 phase, but not inducing apoptosis except at very high concentrations. In a related animal model, canertinib inhibits tumor growth. Separately, canertinib inhibits Akt and ERK1/2 in cells lacking ErbB receptors and induces caspase-mediated apoptosis.

Product Info

Cas No.

289499-45-2

Purity

≥98%

Formula

C24H25ClFN5O3 • 2HCl

Formula Wt.

558.86

Chemical Name

N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6- yl]prop-2-enamide;dihydrochloride

IUPAC Name

N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6- yl]prop-2-enamide;dihydrochloride

Synonym

CI1033

Appearance

Pale yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C0252 MSDS PDF

Info Sheet

C0252 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

Ras-Raf-MEK-ERK Pathway Booklet

References

Djerf Severinsson EA, Trinks C, Gréen H, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8. PMID: 21982771.

Trinks C, Severinsson EA, Holmlund B, et al. The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells. Biochem Biophys Res Commun. 2011 Jul 8;410(3):422-7. PMID: 21669187.

Zinner RG, Nemunaitis J, Eiseman I, et al. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer. Clin Cancer Res. 2007 May 15;13(10):3006-14. PMID: 17505003.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V3479

    Vitamin K3

    Synthetic analog of 1,4-naphthoquinone, precurs...

    ≥98%
  • P6855

    (±)-S-Propyl-L-cysteine-S-oxide

    Organosulfur found in Allium; analog of alliin....

    ≥98%
  • G3353

    Ginkgolic Acid (15:1)

    Found in Ginkgo; HIV protease and fatty acid sy...

    ≥98%
  • E8401

    Evacetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • A5033

    4-Aminosalicylic Acid

    Dihydrofolate reductase inhibitor.

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • P0246

    Palomid 529

    mTOR inhibitor.

    ≥98%
  • C8069

    Curcumin

    Diarylheptanoid found in Zingiberaceae.

    ≥97% curcuminoid content
  • G4782

    Glucoraphenin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • C0264

    L-Carnitine Tartrate

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%
  • C458567

    Clofazimine

    Antibacterial (Antimyobacterial) agent.

    ≥99%
  • A9714

    AZD-1152-HQPA

    AurKA/B inhibitor.

    ≥98%
  • P6957

    Protopanaxadiol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • D178589

    1-Deoxynojirimycin

    Anti-diabetic alkaloid

    ≥98%
  • C3449

    Clodronate Disodium Tetrahydrate

    Non-nitrogen bisphosphonate; mitochondrial ATP/...

    ≥98%
  • S6235

    Spironolactone

    Mineralocorticoid, aldosterone, AR antagonist, ...

    ≥97%
  • J0378

    Jatrorrhizine

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enz...

    ≥96%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only