• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Carnosol

Carnosol

Product ID C0267
Cas No. 5957-80-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $326.70 In stock
25 mg $918.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Carnosol is a diterpene compound originally found in rosemary plants. Carnosol exhibits antidepressant, anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. Carnosol inhibits microsomal prostaglandin E2 (PGE2) synthase and decreases production of pro-inflammatory PGE2; in vivo, it inhibits PMA-induced edema and decreases expression of IL-1β and TNF-α. Carnosol inhibits the epithelial-to-mesenchymal transition (EMT) in ovarian cancer cells and decreases growth and viability in breast, ovarian, and intestinal cancer cells. In colon cancer cells, carnosol increases activation of caspases 3 and 9, induces cleavage of PARP, upregulates expression of p53, downregulates expression of MDM2, and suppresses activation of STAT3, JAK2, and Src. Additionally, this compound inhibits androgen and estrogen receptors, suppressing tumor growth and PSA levels in animal models of prostate cancer.

Product Info

Cas No.

5957-80-2

Purity

≥98%

Formula

C20H26O4

Formula Wt.

330.42

Chemical Name

2H-9,4a-(Epoxymethano)phenanthren-12-one,1,3,4,9,110a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1- methylethyl)-, (4aR-(4aalpha,9alpha,10abeta))-

IUPAC Name

(1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one

Synonym

CCRIS 7122

Melting Point

210-220°C

Solubility

Soluble in DMSO, DMF or ethanol. Sparingly soluble in aqueaous buffers.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

C0267 MSDS PDF

Info Sheet

C0267 Info Sheet PDF

References

Vergara D, Simeone P, Bettini S, et al. Antitumor activity of the dietary diterpene carnosol against a panel of human cancer cell lines. Food Funct. 2014 Jun 28;5(6):1261-9. PMID: 24733049.

Park KW, Kundu J, Chae IG, et al. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. Int J Oncol. 2014 Apr;44(4):1309-15. PMID: 24481553.

López-Jiménez A, García-Caballero M, Medina MÁ, et al. Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Eur J Nutr. 2013 Feb;52(1):85-95. PMID: 22173778.

Machado DG, Cunha MP, Neis VB, et al. Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L. Food Chem. 2013 Jan 15;136(2):999-1005. PMID: 23122155.

Bauer J, Kuehnl S, Rollinger JM, et al. Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1. J Pharmacol Exp Ther. 2012 Jul;342(1):169-76. PMID: 22511203.

Mengoni ES, Vichera G, Rigano LA, et al. Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia. 2011 Apr;82(3):414-21. PMID: 21129455.

Johnson JJ, Syed DN, Suh Y, et al. Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention. Cancer Prev Res (Phila). 2010 Sep;3(9):1112-23. PMID: 20736335.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F4883

    Flutriafol

    Triazole; demethylation inhibitor, NMDA agonist...

    ≥97%
  • N3422

    Nifekalant Hydrochloride

    Voltage-gated K+ channel blocker.

    ≥98%
  • C3263

    Ciprofloxacin Hydrochloride Monohydrate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • K1776

    Ketotifen Fumarate

    H1 histamine and LT antagonist, PDE inhibitor.<...

    ≥98%
  • N3450

    Nimesulide

    NSAID; COX-2 inhibitor.

    ≥98%
  • I7557

    1-Isothiocyanato-6-(methylsulfonyl)-hexane

    Synthetic ITC, erysolin analog.

    ≥98%
  • C0033

    Cafestol Stearate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • C2947

    Chlorpromazine Hydrochloride

    Phenothiazine, FIASMA; D1/2/3/4, 5-HT1/2, M1/2 ...

    ≥98%
  • T2402

    TG100-115

    p110δ and p110γ PI3K inhibitor.

    ≥98%
  • C0171

    Carboplatin

    Pt-based DNA cross-linker.

    ≥99%
  • K040009

    KB-0742 dihydrochloride

    CDK9 inhibitor.

    ≥99%
  • F5871

    N-formyl-Met-Leu-Phe-Lys

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • E9418

    Exendin 3 (9-39)

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%
  • P2410

    Phenethyl Dimethyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • R2353

    RF-NH2

    RF-amide peptide; potential GPR147 agonist, pot...

    ≥95%
  • G681019

    Grapiprant

    EP4 receptor antagonist

    ≥98%
  • L5751

    Lomerizine Dihydrochloride

    L-type and T-type Ca2+ and TRP antagonist.

    ≥98%
  • T6935

    Trimebutine Base

    BK K+ channel and L-type Ca2+ channel blocker.<...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only