Carvedilol

Name: Carvedilol
SKU: C0365
Availability: InStock

Product ID C0365

Cas No. 72956-09-3

Purity ≥98%

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Description

Carvedilol is an α1- and β1/2-adrenergic receptor antagonist used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol also inhibits release of pro-inflammatory cytokines TNF-α and IL-6 and production of eicosanoids PGE2 and LTB4, alleviating oxidative stress and indicating antioxidative and anti-arthritic activities. Additionally, this compound may exhibit anti-atherosclerotic and anti-diabetic activity through its inhibition of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	72956-09-3
Purity	≥98%
Formula	C₂₄H₂₆N₂O₄
Formula Wt.	406.47
Chemical Name	1-(99H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
IUPAC Name	1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
Synonym	Coreg, Dimitone, Eucardic, Kredex, Querto
Melting Point	114-115°C
Solubility	Soluble in DMSO (>20 mg/mL), and methylene chloride. Sparingly soluble in ethanol(4 mg/mL), isopropanol and ethyl ether. Insoluble in water (0.02 mg/mL).
Appearance	White to off white crystalline powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	C0365 MSDS PDF
Info Sheet	C0365 Info Sheet PDF

References

Arab HH, El-Sawalhi MM. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8. PMID: 23360886.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30. PMID: 18629377.

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Carvedilol

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