LKT Labs

Biochemicals for Life Science Research

Carvedilol

Product ID C0365
Cas No. 72956-09-3
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $93.00 In stock
1 g $158.90 In stock
5 g $594.90 In stock
10 g $1,058.20 In stock
Bulk Quote

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Description

Carvedilol is an α1- and β1/2-adrenergic receptor antagonist used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol also inhibits release of pro-inflammatory cytokines TNF-α and IL-6 and production of eicosanoids PGE2 and LTB4, alleviating oxidative stress and indicating antioxidative and anti-arthritic activities. Additionally, this compound may exhibit anti-atherosclerotic and anti-diabetic activity through its inhibition of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

72956-09-3
Purity

≥98%
Formula

C24H26N2O4
Formula Wt.

406.47
Chemical Name

1-(99H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
IUPAC Name

1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
Synonym

Coreg, Dimitone, Eucardic, Kredex, Querto
Melting Point

114-115°C
Solubility

Soluble in DMSO (>20 mg/mL), and methylene chloride. Sparingly soluble in ethanol(4 mg/mL), isopropanol and ethyl ether. Insoluble in water (0.02 mg/mL).
Appearance

White to off white crystalline powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C0365 MSDS PDF
Info Sheet

C0365 Info Sheet PDF

References

Arab HH, El-Sawalhi MM. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8. PMID: 23360886.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30. PMID: 18629377.

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