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Carvedilol

Carvedilol

Product ID C0365
Cas No. 72956-09-3
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $97.70 In stock
1 g $166.80 In stock
5 g $624.60 In stock
10 g $1,111.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Carvedilol is an α1- and β1/2-adrenergic receptor antagonist used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol also inhibits release of pro-inflammatory cytokines TNF-α and IL-6 and production of eicosanoids PGE2 and LTB4, alleviating oxidative stress and indicating antioxidative and anti-arthritic activities. Additionally, this compound may exhibit anti-atherosclerotic and anti-diabetic activity through its inhibition of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

72956-09-3

Purity

≥98%

Formula

C24H26N2O4

Formula Wt.

406.47

Chemical Name

1-(99H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

IUPAC Name

1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

Synonym

Coreg, Dimitone, Eucardic, Kredex, Querto

Melting Point

114-115°C

Solubility

Soluble in DMSO (>20 mg/mL), and methylene chloride. Sparingly soluble in ethanol(4 mg/mL), isopropanol and ethyl ether. Insoluble in water (0.02 mg/mL).

Appearance

White to off white crystalline powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C0365 MSDS PDF

Info Sheet

C0365 Info Sheet PDF

References

Arab HH, El-Sawalhi MM. Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8. PMID: 23360886.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30. PMID: 18629377.

Custom Order

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