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Chlormadinone is a synthetic steroidal progesterone that exhibits anti-androgenic and anti-osteoporotic activities. Chlormadinone is occasionally used as a contraceptive but also treats benign prostatic hyperplasia (BPH) and polycystic ovary syndrome (PCOS). In bone marrow stem cells, chlormadinone promotes osteoblast differentiation and Ca2+ deposition.
| Cas No. | 302-22-7 |
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| Purity | ≥96% |
| Formula | C23H29ClO4 |
| Formula Wt. | 404.93 |
| Chemical Name | 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione |
| IUPAC Name | [(8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-dimethyl-3-oxo-2,8,9, 11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate |
| Synonym | Chronosynl Cyclonorm, Fertiletten, Lormin, Luteran, Matrol, Normenon, Prostal, Traslan |
| Melting Point | 212-214°C |
| Solubility | Soluble in methanol, chloroform, ethyl acetate, ether, DMSO. |
| Appearance | White or Off-white Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Kim JM, Lee JE, Ryu SH, et al. Chlormadinone acetate promotes osteoblast differentiation of human mesenchymal stem cells through the ERK signaling pathway. Eur J Pharmacol. 2014 Mar 5;726:1-8. PMID: 24440171.
Fujimoto K, Hirao Y, Ohashi Y, et al. The effects of chlormadinone acetate on lower urinary tract symptoms and erectile functions of patients with benign prostatic hyperplasia: a prospective multicenter clinical study. Adv Urol. 2013;2013:584678. PMID: 23762042.
Gomes VA, Vieira CS, Jacob-Ferreira AL, et al. Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome. Basic Clin Pharmacol Toxicol. 2012 Sep;111(3):211-6. PMID: 22510229.