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Chloroadenosine

Chloroadenosine

Product ID C2948
Cas No. 146-77-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
10 mg $68.30 In stock
50 mg $89.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chloroadenosine is a nucleoside analog that exhibits anticancer, vasodilatory, and anti-inflammatory activities. Chloradenosine induces double-stranded DNA breaks and apoptosis in lung cancer cells. This compound acts as an agonist at adenosine receptors, inducing arterial dilation. In animal models of lung injury induced by latex particles and Escherichia exposure, chloroadenosine decreases expression of TNF-α.

Product Info

Cas No.

146-77-0

Purity

≥98%

Formula

C10H12ClN5O4

Formula Wt.

301.69

IUPAC Name

(2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3, 4-diol

Synonym

2-Chloroadenosine, 2-CADO, 6-Amino-2-chloropurine riboside

Melting Point

162°C

Solubility

Soluble in methanol.

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C2948 MSDS PDF

Info Sheet

C2948 Info Sheet PDF

References

Duan HY, Cao JX, Qi JJ, et al. E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells. Biochemistry (Mosc). 2012 Mar;77(3):261-9. PMID: 22803943.

Bender SB, Tune JD, Borbouse L, et al. Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood). 2009 Jun;234(6):683-92. PMID: 19307464.

Sakamaki F, Ishizaka A, Urano T, et al. Attenuation by intravenous 2-chloroadenosine of acute lung injury induced by live escherichia coli or latex particles added to endotoxin in the neutropenic state. J Lab Clin Med. 2003 Aug;142(2):128-35. PMID: 12960960.

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