| Product Unit Size | Cost | Quantity | Stock |
|---|
Chloroadenosine is a nucleoside analog that exhibits anticancer, vasodilatory, and anti-inflammatory activities. Chloradenosine induces double-stranded DNA breaks and apoptosis in lung cancer cells. This compound acts as an agonist at adenosine receptors, inducing arterial dilation. In animal models of lung injury induced by latex particles and Escherichia exposure, chloroadenosine decreases expression of TNF-α.
| Cas No. | 146-77-0 |
|---|---|
| Purity | ≥98% |
| Formula | C10H12ClN5O4 |
| Formula Wt. | 301.69 |
| IUPAC Name | (2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3, 4-diol |
| Synonym | 2-Chloroadenosine, 2-CADO, 6-Amino-2-chloropurine riboside |
| Melting Point | 162°C |
| Solubility | Soluble in methanol. |
| Appearance | White powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Duan HY, Cao JX, Qi JJ, et al. E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells. Biochemistry (Mosc). 2012 Mar;77(3):261-9. PMID: 22803943.
Bender SB, Tune JD, Borbouse L, et al. Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood). 2009 Jun;234(6):683-92. PMID: 19307464.
Sakamaki F, Ishizaka A, Urano T, et al. Attenuation by intravenous 2-chloroadenosine of acute lung injury induced by live escherichia coli or latex particles added to endotoxin in the neutropenic state. J Lab Clin Med. 2003 Aug;142(2):128-35. PMID: 12960960.