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Chrysin

Chrysin

Product ID C2968
Cas No. 480-40-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $57.20 In stock
25 g $163.40 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chrysin is a flavone/flavonoid initially found in Passiflora, Oroxylum, and Pleurotis; it is also a byproduct found in propolis. Chrysin exhibits anti-estrogenic, anti-inflammatory, anxiolytic, neuroprotective, cognition enhancing, antioxidative, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. In vitro, chrysin may inhibit aromatase. In macrophages, chrysin inhibits LPS-induced expression of COX-2 and activity of NF-IL-6. This compound displays anxiolytic benefit in animals undergoing the elevated plus maze. In vivo, chrysin increases levels of catalase, superoxide dismutase, and glutathione, decreases activation of NF-κB and levels of TNF-α, IL-1β, IL-6, and caspase 3, and increases body weight and cognitive function. Chrysin inhibits DEN-induced renal carcinogenesis in vivo and decreases expression of VEGF, cellular metastasis, and breast cancer cell survival in vitro and in vivo. Additionally, chrysin inhibits HDAC2 and HDAC8.

Product Info

Cas No.

480-40-0

Purity

≥98%

Formula

C15H10O4

Formula Wt.

254.2

Chemical Name

5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

IUPAC Name

5,7-dihydroxy-2-phenylchromen-4-one

Synonym

5,7-Dihydroxyflavone, chrysidenon

Melting Point

284-290°C

Solubility

Soluble in alkali hydroxide solutions. Slightly soluble in alcohol, chloroform, or ether. Practically insoluble in water.

Appearance

Yellowish powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C2968 MSDS PDF

Info Sheet

C2968 Info Sheet PDF

References

Li R, Zang A, Zhang L, et al. Chrysin ameliorates diabetes-associated cognitive deficits in Wistar rats. Neurol Sci. 2014 Oct;35(10):1527-32. PMID: 24737349.

Lirdprapamongkol K, Sakurai H, Abdelhamed S, et al. A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep. 2013 Nov;30(5):2357-64. PMID: 23969634.

Rehman MU, Tahir M, Khan AQ, et al. Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB. Toxicol Lett. 2013 Feb 4;216(2-3):146-58. PMID: 23194824.

Pal-Bhadra M, Ramaiah MJ, Reddy TL, et al. Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells. BMC Cancer. 2012 May 16;12:180. PMID: 22591439.

Brown E', Hurd NS, McCall S, et al. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA J. 2007 Oct;75(5):333-7. PMID: 17966676.

Woo KJ, Jeong YJ, Inoue H, et al. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett. 2005 Jan 31;579(3):705-11. PMID: 15670832.

Kellis JT Jr, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep 7;225(4666):1032-4. PMID: 6474163.

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