LKT Labs

Biochemicals for Life Science Research

Citalopram Hydrobromide

Product ID C3477
Cas No. 59729-32-7
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $109.30 In stock
100 mg $352.60 In stock
500 mg $1,094.00 In stock
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Description

Citalopram is a selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter (SERT); citalopram is clinically used for its antidepressant and anxiolytic activities, although it may prolong the QT interval. The S-isomer of citalopram is active and is sold on its own as escitalopram. Citalopram also exhibits neuroprotective activity, increasing expression of BDNF and inhibiting neuronal apoptosis. Additionally, this compound displays anti-inflammatory benefit, inhibiting arthritis progression in vivo by suppressing TLR signaling and decreasing production of TNF, IL-6, and IFN-γ.

Product Info

Cas No.

59729-32-7
Purity

≥98%
Formula

C20H21FN2O • HBr
Formula Wt.

405.31
Chemical Name

(RS)-1-[3-(dimethylamino)propyl]-1-(p-flurophenyl)- 5-phthalancarbonitrile, hydrobromide
IUPAC Name

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5- carbonitrile;hydrobromide
Synonym

Celexa, Cipramil, Elopram, Seropram.
Melting Point

182-183°C
Solubility

DMSO (18 mg/ml) Water (4 mg/ml) Ethanol (20 mg/ml)
Appearance

White powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C3477 MSDS PDF
Info Sheet

C3477 Info Sheet PDF

References

Tan Y, Duan J, Li Y, et al. Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression. Pharmazie. 2010 Nov;65(11):845-8. PMID: 21155393.

Sacre S, Medghalchi M, Gregory B, et al. Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Arthritis Rheum. 2010 Mar;62(3):683-93. PMID: 20131240.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

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